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NIH’s All of Us Research Program returns genetic health-related results to participants

News Release

Tuesday, December 13, 2022

Landmark precision medicine effort returns value to research participants by sharing tailored, actionable health-related reports.

The National Institutes of Health’s All of Us Research Program has begun returning personalized health-related DNA results to more than 155,000 participants, with reports detailing whether participants have an increased risk for specific health conditions and how their body might process certain medications. This marks a major milestone for the program, delivering on its promise to share information and return value to participants.

“Knowledge is powerful. By returning health-related DNA information to participants, we are changing the research paradigm, turning it into a two-way street – fueling both scientific and personal discovery that could help individuals navigate their own health,” said Josh Denny, M.D., M.S., chief executive officer of the All of Us Research Program. “This type of partnership with our participants is crucial for building trust and fulfilling the commitment we made to drive research that can offer meaningful insights for all.”

All of Us aims to partner with at least 1 million people who reflect the diversity of the United States to accelerate medical breakthroughs. About 80{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} of All of Us participants represent communities that have been historically underrepresented in medical research, and nearly 50{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} of All of Us participants identify with a racial or ethnic minority group. The program started returning genetic ancestry and trait results to participants in December 2020. So far, the program has offered genetic ancestry and traits results to more than 175,000 participants and continues to return about 6,000 results each month.

In this first phase of returning health-related DNA results, participants who provided a blood sample and consented to receive genomic information are being individually invited to receive their results. They can choose which health-related results they want, if any. Those who choose to receive results will get an alert several weeks later when their results are ready. Additionally, genetic counselors are available to meet with participants and their family members or health care provider to discuss and interpret their results.

The program’s Hereditary Disease Risk report, informed by recommendations from the American College of Medical Genetics and Genomics, includes 59 genes and variants that are associated with serious, medically-actionable health conditions. These genes are linked with an increased risk of specific cancers, heart conditions, blood disorders, and more. The program anticipates that 2-3{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} of participants will receive a result showing a pathogenic or likely pathogenic variant linked in one of the genes included in the report. Those whose results show they may have an increased risk of a serious health condition will be offered a clinical DNA test through the program’s genetic counseling resource, conducted outside of the program at no cost. This clinical DNA test will be conducted by Color Health, which provides genetic counseling services to All of Us participants.

Participants can also choose to receive a Medicine and Your DNA report that includes seven genes that are known to affect how the body processes certain medicines. Nearly all participants will learn more about how their bodies process medicines based on these results, however, participants are advised to consult a health care provider and undergo the appropriate clinical testing prior to considering changes to medications.

“Our participants care about their health as well as medical research. We strive to share information with them in a responsible, accessible, and impactful way that honors their trust in us and provides them with tools to continue to learn more about their own health,” said Karriem Watson, D.H.Sc., M.S., M.P.H., “This intentional focus brings us one step closer to advancing health equity for our participants and can serve as a catalyst for change to increase representation in medical research.”

“Returning information in research programs is the ethical choice, but must be done responsibly and equitably,” said Alicia Zhou, Ph.D., chief science officer of Color Health, the Genetic Counseling Resource for the All of Us Research Program. “All of Us is setting a new precedent for longitudinal research programs.”

All of Us works with a consortium of national and community partners across the United States to help reach people and collect DNA samples and data from surveys, physical measurements, electronic health records (EHRs), and wearable devices. The program’s Data and Research Center, Participant Technology Systems Center, and Genetic Counseling Resource worked closely with the program and other partners to develop the process for returning health-related genetic results. The program’s Biobank and Genome Centers collaborated to generate the genomic data that informs the personalized results.

The program plans to increase the number of participants who are invited to receive genetic health-related results throughout 2023, including new participants who join the program.

All of Us is a registered service mark of the U.S. Department of Health & Human Services (HHS).

About the All of Us Research Program: The mission of the All of Us Research Program is to accelerate health research and medical breakthroughs, enabling individualized prevention, treatment, and care for all of us. The program will partner with at least 1 million people who reflect the diversity of the United States to build one of the largest, most diverse biomedical data resources of its kind. Data is made available to researchers to drive scientific discoveries into the biological, environmental, and behavioral factors that influence health and disease. For more information, visit www.ResearchAllofUs.org, www.JoinAllofUs.org, and https://www.AllofUs.nih.gov/.

About the National Institutes of Health (NIH):
NIH, the nation’s medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.

NIH…Turning Discovery Into Health^®

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Online Fitness & Nutrition Program for People 60 & Over, Fitat60 Celebrates its First 10,000 Members

With hundreds of five-star reviews, Fitat60.com is rapidly gaining momentum with those over 60.

MELBOURNE, AUSTRALIA, December 6, 2022 /EINPresswire.com/ — Having just turned two years old, Fitat60 has recently hit a few big milestones. An innovative online fitness and nutrition program designed specifically for people 60 and over, the site is celebrating 10,000 members and an average 4.4 rating on Trustpilot, while November was its biggest month yet. According to Editor-in-Chief Matthew Morgan, the business is gearing up for even greater success in 2023.

“Fitat60 is really taking off,” says Morgan. “I can’t say that we’re totally surprised, because we really did our homework to find out what people over 60 were looking for, but we’re delighted by all the positive comments we’ve been receiving.”

The idea for the business came at the beginning of the pandemic, when people started turning to the internet to find ways to get fit and stay healthy. With most programs focusing on a younger audience, there was an obvious gap in the market for the over sixty crowd.

“When we conducted our research, we were astonished to learn that most over-sixties are far from being the stereotypical elderly folks we see in the media. They are not, for the most part, grey-haired, hunched over or immobilized by bad backs and bad knees—quite the contrary, in fact. Feeling good, positive about life and with plenty of energy, the majority are always on the lookout for ways to improve their health and well-being. Not that they don’t have ailments or issues—they do, but it doesn’t define them. As many of our clients say: 60 is the new 40!”

Focusing squarely on the needs of those people, Fitat60 offers a four-part program:

• Nutrition: an extensive range of recipes and meal plans to show that eating healthy doesn’t have to mean eating without flavor.

• Fitness: easy-to-follow videos conducted by certified personal trainers, catering for all levels of fitness.

• Mind: tips and tricks to keep an active mind and a positive outlook.

• Medical: help to explain GPs advice, and practical pointers on how to put this advice into practice.

“60 is the new 40!” Morgan concludes. “We invite you to invest in your greatest asset—yourself—by joining our program!”

For more information, visit the website at https://fitat60.com.

About the Company

Founded by Lyndal Payne and Matthew Morgan in 2020, Fitat60 is an Australian-based online fitness and nutrition program for people over the age of 60. On a mission to find and develop the best and relevant products, programs and supplements with no corners cut, the owners have a decade’s worth of experience in building and producing online fitness and nutrition content and video production.

Matthew Morgan
Fitat60
+61438568902 ext.
matt@fitat60.com

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Mercato Announces Launch of Thriving Communities Program, eCommerce Platform Increases Healthy Food Access and Grows Small Businesses in Low-Income Communities

Initial roll-out in New York City proves program increases sales for the independent grocer while providing residents with greater choice and convenience. Platform can accelerate online SNAP purchases and provide other healthy food incentives.

SAN DIEGO, Nov. 21, 2022 /PRNewswire/ — Mercato, the nation’s leading eCommerce platform for independent grocers, has announced its new initiative to improve access to healthy foods and foster economic stability in low-income communities.

Thriving Communities works with local governments, private funders and non-profits to bring more grocers onto the eGrocery platform so they can digitize their inventory, offer delivery and enable enrollment and utilization of SNAP online.

It creates what founder and CEO Bobby Brannigan calls “The Mercato Effect” – whereby grocers going online provides residents access to healthy, culturally appropriate foods and the ability to redeem public/private food benefits which in turn creates more jobs, increases grocers’ sales and keeps dollars circulating within the community.

“As the son of an independent grocer in Brooklyn, I know first-hand how critical these independent, local grocers are to the economic and social well-being of their communities,” said Brannigan. “They are the lifeline for so many residents to get fresh, healthy, culturally relevant foods without having to travel far or wait weeks to go to the market. By giving local grocers the tools and technologies to operate online, they can increase their own revenue and fuel healthier ecosystems throughout the country.”

New York City was the first city to partner with Mercato, leveraging Thriving Communities to test a technological pilot that offered subsidized groceries to a cohort of New Yorkers.

“The pandemic challenged food security in unprecedented ways,” said Kate MacKenzie, executive director, New York City Mayor’s Office of Food Policy. “Mercato’s innovative work piloting online grocery benefits making healthy, affordable groceries accessible to all New Yorkers, no matter where they live. New York City is proud to innovate with technology and public benefits, and we are thrilled that Mercato recognizes this too.”

“Getting onto the Mercato platform was game-changing for our store and our shoppers,” said Gustavo Rodriguez of Key Food Stadium, located in the Bronx. “Our sales are increasing literally every day, especially fresh produce, and the technology and service Mercato provides enables us to fulfill orders seamlessly and with the same personal attention and care that our shoppers need and deserve. It feels incredible to be feeding and helping low-income residents in our community.”

Mercato is looking to expand Thriving Communities by finding and collaborating with partners in other cities including Chicago, Boston, Baltimore, Philadelphia and Los Angeles.

For more about Mercato Thriving Communities, the impact it can have and how to get involved visit www.mercato.com/thrive

About Mercato

Mercato is an eCommerce and local delivery platform that provides thousands of independent grocers across the country with the tools and technologies they need to stay competitive in the marketplace. Headquartered in San Diego, CA, it was founded by Bobby Brannigan, the son of a neighborhood grocer in Brooklyn, who saw his father needed to modernize his inventory and delivery systems to stay in business and better serve his shoppers. Since launching in 2015 Mercato has brought more than 1,500 stores across the country onto the platform.

Press Contact: Richard Shea, Shea Communications (917) 584-3542

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SOURCE Mercato

“Life-Changing” Fitness & Nutrition Program Is Designed For All Levels

This Patch posting is sponsored by The Max Problem of Pine Brook.

Nearby firms are the coronary heart of our communities. Patch experienced a possibility to talk with Ingrid Segev, Proprietor/Instructor of The Max Challenge of Pine Brook.

Patch: Convey to us a little bit about your enterprise or business:
Ingrid Segev: The Max Challenge of Pine Brook is a daily life-switching 10-week health application built for all amounts. Our application is a culmination of cardio, toughness schooling and nourishment guidance. Our 45-minute dwell teacher led courses are designed to hold you going whilst strengthening your cardio and toughness conditioning through the 10 weeks. The team setting builds a strong assist method to aid you achieve your plans! Our nourishment strategy offers distinct pointers and portion regulate enabling you to adhere to a basic, healthy diet approach to make you come to feel improved, a lot more energetic and eliminate those people pounds!

Patch: How extended have you been carrying out company in city?
Segev: 5 yrs.

Patch: What attracted you to the line of work you are in, and how did you get started out?
Segev: I think motion is mood. By simply lacing up your trainers, you get charge of your working day, your angle, your zen and your aura.

I was elevated in Lake Telemark, a Scandinavian local community in Morris County’s Rockaway Township that applied to be referred to as “Little Norway.” My affinity for conditioning started off young.
For as very long as I can try to remember, I have been included in sports. When I was 8 yrs outdated I was working out to “Get in Condition Lady” in my residing space. If you grew up on the ’80s, you likely know what I am chatting about. It was a well-known exercise from the ’80s for youthful ladies with catchy music, ribbon twirling, verbal exercise session cues and gentle dumbbells. I beloved it so significantly I even wrote about it in my childhood diary that I even now have.

For as very long as I can bear in mind, I have been concerned in sporting activities and outdoor actions. I’m Norwegian, so in a natural way I really like downhill and cross-state snowboarding (wink, wink), and they keep on being large passions in my lifetime. I did monitor and subject in high college, throwing the javelin (I even held my university report, alongside with two other women, for the three-women of all ages staff toss!) Then there was soccer, softball and traveling close to the place with my competition cheerleading workforce.

So, certainly, I’ve usually been energetic … but I never felt like I was wholly in condition. (Audio familiar?) My accurate fitness journey began in 2009 when I qualified for and completed my initial complete marathon. It was a satisfying knowledge that kicked off a renewed curiosity in my bodily exercise. But just a handful of several years afterwards, in 2017, my planet nearly stopped when I identified out I had thyroid cancer and had to have a thyroidectomy. After my restoration, I decided to shell out nearer attention to the foodstuff I was deciding upon. (I was cancer-cost-free, and determined to do suitable by my system!) By discovering to merge healthful taking in with an active life-style, I commenced to reap the benefits of feeling completely nutritious, satisfied, and toned—and I haven’t appeared back!

Patch: If you experienced to sum up your business mission to a stranger in 5 terms, what would those text be?
Segev: Health and fitness. Diet. Determination. Effects= Happiness

Patch: What is the major problem or most tough second you’ve faced in your job?
Segev: We have hundreds of associates, and the most significant obstacle is earning guaranteed they are continually inspired to aid achieve their physical fitness objectives.

Patch: What is the most enjoyable aspect of your work?
Segev: Looking at associates every day reaping added benefits of healthier and happier life-style in their health journey. I am continually get phone calls/texts from our users, excitedly sharing how much greater they come to feel, they’re off meds, their blood perform has enhanced. This is why I like what I do.

Patch: How would you say your enterprise or firm distinguishes itself from the other folks?
Segev: We are substantially diverse that your “normal” fitness center. We definitely are the only health and fitness center that is tremendous welcoming and conditioning for all ranges. Think of an extremely supportive fitness community.

Patch: What is the finest piece of advice you’ve ever been specified when it comes to results?
Segev: Do what you adore and it won’t really feel like work.

Patch: Are there any new assignments or endeavors you are performing on that you’re added fired up about?
Segev: Functioning on enjoyable exercise programs for our upcoming 10 Week Obstacle.

Perot family donates $50M to UT Southwestern dual-degree program for medical researchers

A $50 million donation from the Perot household will pave way for the expansion of a single of the best health-related study diploma courses in the nation, UT Southwestern Medical Center announced Thursday.

The gift will establish a permanent endowment for UT Southwestern’s twin M.D./Ph.D diploma application, which trains health-related researchers and is 1 of 54 such courses in the country that is supported by the National Institutes of Health.

The program will be renamed the Perot Family members Scholars Health care Scientist Instruction System. Funding will permit for far more learners to be recognized into the method and develop exploration disciplines to contain biomedical engineering, computational biology, bioinformatics and details science, according to a news release.

“This extraordinary gift delivers a long-lasting foundation at UT Southwestern for this unique twin-degree method that will not only reward top rated UT Southwestern college students but also assistance address a disturbing nationwide development in the diminishing quantity of thoroughly qualified medical professional-scientists,” stated Dr. Daniel K. Podolsky, president of UT Southwestern. “The Perot family’s beneficent guidance further cements their historic determination to the constant progression of academic drugs and its added benefits.”

According to the news launch, the funding will support UT Southwestern recruit students from elite U.S. faculties and enable gifted researchers to continue to be in the U.S. for their occupations. The system admits about 10 to 12 college students every yr, according to Russell Rian, a UT Southwestern spokesman.

About 300 medical doctor-experts have graduated through the system because its start in 1978. A lot of graduates have held college positions at prestigious clinical centers, in accordance to UT Southwestern.

Dr. Andrew Zinn, dean of the UT Southwestern Graduate School of Biomedical Sciences, graduated through the method, which he mentioned was central to his occupation in medical exploration all around human genetics. Zinn is also the director of the healthcare scientist training system.

“I just want to say how fascinating this is and how substantially we foresee this present to be transformative,” Zinn said.

Margot Perot, the widow of philanthropist, developer and previous presidential candidate Ross Perot, explained her husband as an “enthusiastic supporter” of the system.

Perot family donates M to UT Southwestern dual-degree program for medical researchers — From still left: Carolyn Perot Rathjen, Nancy Perot, Ross Perot Sr., Margot Perot, Ross Perot Jr., Suzanne Perot McGee and Katherine Perot Reeves.(UT Southwestern Health-related Middle)

The Perot relatives 1st invested in packages at UT Southwestern in 1987 via a $20 million present to support Nobel laureates Michael Brown and Joseph Goldstein, as effectively as the health-related training system, according to the news launch. The relatives gave an supplemental $23 million in 1996 to aid coaching and biomedical investigation at UT Southwestern.

The Perots have supported other initiatives at UT Southwestern, together with the Perot Basis Neuroscience Translational Analysis Middle, psychological health and fitness systems and exploration similar to Gulf War syndrome.

“Our loved ones is delighted to sustain our assist and association” with the application, Perot said in a penned assertion. “We know that it will produce huge rewards in the yrs to appear. We are certain our resources will go much to teach younger researchers destined to make substantial medical breakthroughs in the foreseeable future.”

Brown explained the donation as “enormously forward-hunting.”

“This most current gift will make it feasible for us to generate a complete new generation of health practitioner-experts who will then go on to build new cures and in the long run the suggests to avert many illnesses,” he said.