Study reveals new insights into body salt handling

by Marshall University Joan C. Edwards School of Medicine

Study reveals new insights into body salt handling
Proximal tubule specific Atp1a1 ablation. Scheme for generation of RPT-specific Atp1a1 knockout mouse model using a Cre/Lox approach (a). DNA genotyping for homozygous floxed NKA α1 (b) and heterozygous SGLT2-Cre (c). Mice positive for homozygous floxed α1 and heterozygous SGLT2-Cre were grouped as RPTα1-/- and mice positive for homozygous floxed α1 but negative for SGLT2-Cre were grouped as controls RPTα1+/+. Representative blots of NKA α2 and NKA α3 in RPTα1-/- and RPTα1+/+ cortex (120 g) with control mouse brain (30 g) used as positive control (4-month male), and their respective Ponceau S- stained blots as loading control (d-e). Credit: The FASEB Journal (2023). DOI: 10.1096/fj.202200785RR

A new study led by Marshall University researchers focuses on a novel mechanism of the body’s regulation of salt balance.

The kidney plays a central role in the body’s ability to maintain an appropriate sodium balance, which is critical for the determination of blood pressure. Disorders of sodium balance contribute to the development and progression of many common diseases, including hypertension, heart disease and stroke.

Na/K-ATPase (NKA) is the enzymatic machinery that drives absorption of sodium along the renal proximal tubule. As such, it makes quite an unlikely candidate as a molecular counteractor of sodium absorption. In contrast, the Xie model for NKA receptor/signaling, named for the late Zijian Xie, Ph.D., predicts that NKA has evolved as the perfect molecular entity to sense intracellular sodium and coordinate the cellular response to temper absorption and maintain a steady delivery to the distal tubule.

Using gene targeting in cells and mice to test the respective contributions of NKA signaling and ion pumping to the overall regulation of renal sodium reabsorption, the study revealed that NKA signaling is functionally dominant over NKA ion pumping in the control of renal sodium reabsorption, according to new research published earlier this month in The FASEB Journal.

“This paper represents a major advance and a paradigm shift in renal physiology/mammalian salt handling,” said Sandrine Pierre, Ph.D., interim director of the Marshall Institute for Interdisciplinary Research and the corresponding author on the study. “To date, it is the most tangible proof of the validity and physiological significance of the Xie model for sodium pump signaling.”

Expertise in renal physiology and genetic approaches in experimental models to evaluate the non-classical Na/K-ATPase receptor function was provided by a cross-departmental team of investigators from the Marshall Institute for Interdisciplinary Research (MIIR) and the Joan C. Edwards School of Medicine. Xie, a pioneer of NKA non-ion pumping function, was a driving force behind this project from its inception.

“Developing the first genetic mouse model targeting NKA in renal proximal tubule cells has allowed us to unmask the dual antagonistic roles of NKA in renal Na+ and water reabsorption,” said Shreya Mukherji, Ph.D., a scientist in the rare disease DDU at Takeda Pharmaceuticals U.S.A., Inc. and first author on the study, who conducted major portions of this research as a biomedical graduate student at Marshall University.

“However, this is just a stepping stone. Using similar approaches, our group and others will likely dissect new regulatory networks and identify new targets in the management of hypertensive disorders and other highly prevalent chronic conditions.”

More information:
Shreya T. Mukherji et al, Na/ K‐ATPase signaling tonically inhibits sodium reabsorption in the renal proximal tubule, The FASEB Journal (2023). DOI: 10.1096/fj.202200785RR

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Best Fitness Book: 10 Best Books on Health, Fitness & Nutrition

Many of us don’t consider conferring a book on the topic when we set a health or fitness goal. But there are many health and fitness books available in the market that are packed with useful information and might help us get closer to the objectives we’re pursuing.

Look for a book that explains the “why” behind the “what” if you want to start a new training regimen or style of exercise. It is easier to stay motivated if you comprehend the purpose of the activity. Nutrition books can guide you in making thoughtful dietary changes, and cookbooks can give you all the motivation you need. Consider reading books that offer sample meal plans for specific requirements like weight loss, muscle building, or a medical condition like diabetes.

All books on fitness should be thorough and written by experts with the appropriate qualifications. Ensure the book fits your objectives by looking up the author’s background or professional experience.

Here is the list of the best Fitness, Health and Nutrition books.

Best Books on Fitness, Nutrition & Health

The Fitness Mindset by Brian Keane

Best Fitness Book: 10 Best Books on Health, Fitness & NutritionTeam ProductLine

We selected “The Fitness Mindset” as our top overall pick because it is a comprehensive guide to leading a fitter, more active life. Your eating habits, exercise routine, and capacity for motivation will all be strengthened throughout the book by fitness expert Brian Keane.
Keane is here to help, making this a great choice for anyone interested in health, fitness, and personal development, whether you’re looking to change your diet, put in more time at the gym, or simply have more energy to get through the day.
Buy now.

The One-Minute Workout by Martin Gibala

Best Fitness Book: 10 Best Books on Health, Fitness & NutritionTeam ProductLine

Finding the time to exercise is challenging for many of us, not optimising a workout. The author of “The One-Minute Workout,” kinesiologist Martin Gibala, PhD, understands this and shares eight fundamental interval workouts and four micro-workouts that can be used as an alternative to increase strength and endurance quickly.
You’ll learn from this educational read that having endless time doesn’t necessarily mean you’ll get fit.
Buy now.

Glute Lab by Bret Contreras & Glen Cordoza

Best Fitness Book: 10 Best Books on Health, Fitness & NutritionTeam ProductLine

This fitness book is the ultimate guide for strengthening your glutes, your body’s largest muscle. Concentrating only on your glutes may seem odd, but it is essential to all kinds of fundamental movements (like running, jumping, and weight-lifting). You can build strength elsewhere by developing it there.
Bret Contreras, PhD, CSCS, a personal trainer, distils a tonne of field research and scientifically sound training methods throughout the book into an easy-to-follow training manual for building glute strength.
Additionally, this fitness book gives you a specific objective to concentrate on as you begin strength training.
Buy now.

Ready to Run by Kelly Starrett

Best Fitness Book: 10 Best Books on Health, Fitness & NutritionTeam ProductLine

Anyone who runs frequently or wants to start running more should read “Ready to Run,” a fitness book. In this educational book, coach and physiotherapist Kelly Starrett, PhD, offers advice on how to deal with and prevent various problems that runners may run into, such as injuries, inadequate training, difficulties with changing running shoes, and more.
Starrett teaches runners how to run faster, better, stronger, and injury-free by emphasising 12 basic performance standards.
Buy now.

Good to Go by Christie Aschwanden

Best Fitness Book: 10 Best Books on Health, Fitness & NutritionTeam ProductLine

Establishing a fitness routine largely entails working out, but recovery time is equally important. And precisely that is what makes “Good to Go” worth reading. What is the best way to aid your body in recovering from a workout? asks journalist and athlete Christie Aschwanden in her book, which delves into the complicated field of rest and recovery research.
Aschwanden will assist you in determining which cutting-edge recovery techniques are worthwhile incorporating into your routine and which ones you’d be better off avoiding by keeping the focus where it belongs—on science.
Buy now.

Breathwork by Valerie Moselle

Best Fitness Book: 10 Best Books on Health, Fitness & NutritionTeam ProductLine

Yoga instructor Valerie Moselle provides a helpful manual for incorporating breathing exercises and meditation into your day in her book “Breathwork.” She begins by deconstructing the fundamentals of breathwork and investigating the potential advantages of enhancing the mind-body connection. Then, she provides a three-week training programme with easy, step-by-step exercises to add more meditation to your mornings and evenings.
Buy now.

No Sweat by Michelle Segar

Best Fitness Book: 10 Best Books on Health, Fitness & NutritionTeam ProductLine

“No Sweat” isn’t just a book about working out; it’s also about maintaining motivation while working out. Michelle Segar, PhD, a motivation scientist, reviews years of research on exercise and motivation throughout this fitness book.
Even better: She summarises that research into a four-point plan to approach your fitness goals with dedication, vigour, and perhaps even enthusiasm.
Buy now.

Complete Food & Nutrition Guide by Roberta L. Duyff

Best Fitness Book: 10 Best Books on Health, Fitness & NutritionTeam ProductLine

Anyone wanting to comprehend nutrition should consult “The Academy of Nutrition and Dietetics Complete Food and Nutrition Guide.” The 816-page book is jam-packed with reliable details about dietary recommendations, health issues, and nutritional trends—directly from the sources.
What’s lovely? The book avoids becoming overly technical. Instead, author Roberta Larson Duyff concentrates on explaining the information in simple terms so that readers can easily understand how they can apply science to their lives.
Buy now.

Eat to Love by Jenna Hollenstein

Best Fitness Book: 10 Best Books on Health, Fitness & NutritionTeam ProductLine

Despite being written by a nutritionist, “Eat to Love” is not a diet book. It is instead a study of mindful eating. In order to help readers better understand their relationships with their bodies—and how food plays a role in those relationships—Jenna Hollenstein draws on intuitive eating, mindfulness, and mindfulness techniques.
The result is a nutrition guide that encourages you to prioritise your physical and mental health the next time you eat.
Buy now.

Fitness Habits by Amaresh Ojha & Subhra Moitra

Best Fitness Book: 10 Best Books on Health, Fitness & NutritionTeam ProductLine

Who wouldn’t want to be fitter? We all do, and we seek immediate outcomes. Most of us find incorporating fitness into our lifestyles difficult due to a lack of time, motivation, and guidance. So many of us begin with great enthusiasm but eventually give up. This book is a step-by-step manual that will help you win the game and incorporate fitness into your daily life if you have tried to maintain your fitness regimen but have difficulty sticking to it. The book Fitness Habits collects a wealth of research and studies that refute the most widely held beliefs about fitness. This book offers tried-and-true strategies for maintaining your fitness regimen and assists you in developing a daily desire to return to it.
Buy now.

FAQs: Best Fitness, Health and Nutrition Books

Q1. What are the things to consider before planning a fitness program?

Ans. Since there is no one-size-fits-all solution for designing a fitness programme, certified personal trainers usually customise their plans for each client. If you plan to use a fitness book as a personal trainer replacement, you should first think about your goals, available resources, time, level of activity, and fitness before searching for a book that can help you get from where you are to where you want to be.

Q2. What are the benefits of reading fitness books?

Ans. Although the topics covered in fitness books vary, you can count on learning new information and getting new perspectives. You could pick up advice on exercising correctly, eating healthily, getting ready for a race or competition, and more. In some books, case studies or clinical trials are discussed. The author relays the information in plain language and explains how it is pertinent.
A sample workout routine or meal plan is also included in some fitness books. Fitness books are a wealth of knowledge, but their value will be increased if you apply what you’ve learned to your exercise regimen.

Q3. How to make sure that the fitness book will help?

Ans. You can make sure a fitness book is a good fit for you by researching it. Read the book’s synopsis and any information provided in the book. You can get an idea of what to expect by reading the first chapter of a book before purchasing it from some online retailers.
It’s also beneficial to read customer testimonials. Some reviewers disclose details about themselves and their circumstances that might be relevant to you. It can help you decide whether the book will benefit you by reading the viewpoints of someone with similar objectives.

Disclaimer : The above content is non-editorial and produced by a third party advertiser. Times Internet Limited/ Economic Times does not guarantee, vouch for or endorse any of the content or its genuineness. The product prices mentioned in the article are subject to change including depending upon offers given by Amazon.

The FDA won’t approve medical devices vulnerable to cyberattack

The majority of digital medical devices (53{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f}) in the US, as well as internet-connected tools in hospitals, are at risk of cyberattack, according to a 2022 FBI report.

The US Food and Drug Administration (FDA) wants to change that, and has published new approval guidance that addresses the issue. Starting March 29, following directives contained in the federal omnibus spending bill, the FDA will reject applications for any cyber medical device that does not include a cyberattack protection plan.

The agency defines a cyber medical device as any medical device that has software capability or can be connected to the internet.

Most digital medical devices are vulnerable to attack

According to the 2022 FBI report, each of the medical devices currently on the market has on average 6.2 vulnerabilities to cyberattacks, and there have been recalls for insulin pumps and pacemakers that were found to have particularly serious security issues. For end-of-life devices, as many as 40{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} of devices have no protection at all against attacks, the report found.

This means that a large number of health devices, many of which are lifesaving, are susceptible to attack. The list provided by the FBI included insulin pumps, intracardiac defibrillators, and pacemakers. “Malign actors who compromise these devices can direct them to give inaccurate readings, administer drug overdoses, or otherwise endanger patient health,” said the report.

While such direct attacks have not yet occurred, about half of all hospitals have been targeted with ransomware, and nearly as many believe the attacks ended up affecting their patients’ care, too.

What comes next for digital medical device security?

Going forward, FDA approval of digital medical devices will depend on their sponsors providing evidence that their products are reasonably safe against cyber attacks, and submitting a plan to “monitor, identify, and address” any vulnerabilities and threats.

Until Oct. 1, 2023 , devices that have already been submitted for premarket approval before will not receive a refusal to accept from the FDA, which will instead work with the manufacturers and sponsors to obtain relevant information to assess their safety.

The guidance is only valid until 2025 at the latest, as the omnibus bill requires the FDA to update its cybersecurity guidance every two years at the most, to keep up with updates in threats and technology.

New Zealand rugby-inspired program tackles obesity

Obesity has been continuously increasing across the globe at an alarming rate. In New Zealand (NZ), around 31{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} of adults are obese, and 35{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} are overweight, with the prevalence of overweight men significantly greater than women. Notably, Māori and Pasifika men are more obese than non-Māori and non-Pasifika men. Therefore, there is a need for effective and sustainable means of intervention to address issues related to being overweight and obese among NZ men.

New Zealand rugby-inspired program tackles obesity

Study: Rugby Fans in Training New Zealand (RUFIT NZ): a randomized controlled trial to assess the effectiveness of a healthy lifestyle program for overweight men delivered through professional rugby clubs. Image Credit: Peopleimages.com – Yuri A / Shutterstock.com

Background

Men are mostly underrepresented in the majority of weight loss programs. Based on the reports of fourteen randomized controlled trials (RCTs) linked to men-only weight loss and maintenance programs, a combined intervention of exercise, dietary, and behavior change techniques was found to be most effective.

Motivated by the positive results of a previously developed Football Fans in Training (FFIT) program in Scotland, a similar program was designed in NZ. This new program was developed to support obese or overweight NZ men through professional rugby clubs.

A pilot RCT of Rugby Fans in Training-NZ (RUFIT-NZ) was conducted using 96 participants. Notably, this study documented a weight loss of around 2.5 kg among the participants after 12 weeks of intervention.

In addition to the weight loss, these participants exhibited a decrease in resting heart rate, waist circumference, and diastolic blood pressure. An overall improvement in fitness level was also observed.

Importantly, all participants who completed the program strongly recommended this program to their friends, thereby indicating the possibility of broader acceptance of RUFIT-NZ. Thus, a large-scale RCT was required to assess its sustained effect.

A recent International Journal of Behavioral Nutrition and Physical Activity study determines the efficacy and cost-effectiveness of RUFIT-NZ on lifestyle change, fitness, weight loss, blood pressure, and health-related quality of life (HRQoL).

About the study

A two-arm, multi-center, and parallel RCT was conducted in NZ between January 21, 2019, and October 22 22, 2020. RUFIT-NZ was delivered to participants by professional rugby franchises in a 12-session program.

This study cohort included overweight men between 30 and 65 years of age. These study participants were initially screened through the Physical Activity Readiness Questionnaire (PAR-Q). Any participants who were already associated with other healthy lifestyle programs were excluded. 

Weight changes, the primary outcome, were recorded after 52 weeks of intervention. In addition, secondary outcomes such as changes in waist circumference, cardiorespiratory and musculoskeletal fitness, blood pressure, lifestyle behaviors, and HRQoL were evaluated at 12 and 52 weeks.

A total of 308 participants were recruited and randomly divided into two arms, each comprising 154 men. Notably, the study cohort constituted 150 Māori participants.

A wait-list control approach was adopted for the control group, in which participants randomly assigned to this group were asked to continue with their routine lifestyle for 52 weeks. Following this, they were offered RUFIT-NZ intervention at the end of the 12-month follow-up period.

Each RUFIT-NZ intervention session included workshop-based education where the participants learned about the importance of nutrition, sleep, physical activity, and sedentary behavior for about one hour. The following session included one hour of exercise training for the treatment group. Although this was a group-based session, each participant’s exercise was tailored to their individual needs.

Study findings

RUFIT-NZ interventions had overall sustained changes in weight, physical fitness, waist circumference, self-reported physical activity, alcohol consumption, and HRQoL in the treated group. However, no significant change was observed in blood pressure or sleep post-RUFIT-NZ intervention.

Taken together, 200 participants completed the RUFIT-NZ intervention before the implementation of coronavirus disease 2019 (COVID-19) restrictions. The intervention group reported higher consumption of fruits and vegetables at 12 weeks.

At 52 weeks, this group revealed a weight loss of around 2.77 kg. In addition, waist circumference reduction, high physical activity levels, and HRQoL were reduced at 12 and 52 weeks.

The effectiveness of this intervention was also analyzed based on cost per quality-adjusted life year (QALY). Incremental cost-effective ratios of $259 per kg lost or $40,269 per QALY were obtained. A marginal gain in QALY was attributed to the short testing period. 

Conclusions

One of the critical limitations of the present trial was related to the lockdowns and restrictions implemented during the COVID-19 pandemic. Due to these restrictions, the RUFIT-NZ intervention could not be delivered to some participants. However, based on the advice of the trial steering committee, data were analyzed for participants from the first two waves.

Another limitation of this study was the absence of blinded outcome assessments. 

Despite these limitations, the overall positive primary and secondary outcomes emphasized the efficacy of this intervention in preventing the possible adverse events of morbidity and mortality due to obesity.

Journal reference:

  • Maddison, R., Hargreaves, E. A., Jiang, Y., et al. (2023) Rugby Fans in Training New Zealand (RUFIT NZ): a randomized controlled trial to assess the effectiveness of a healthy lifestyle program for overweight men delivered through professional rugby clubs. International Journal of Behavioral Nutrition and Physical Activity 20 (37). doi:10.1186/s12966-022-01395-w, https://ijbnpa.biomedcentral.com/articles/10.1186/s12966-022-01395-w

A Progress Check on Hospital Price Transparency

For decades, U.S. hospitals have generally stonewalled patients who wanted to know ahead of time how much their care would cost. Now that’s changing — but there’s a vigorous debate over what hospitals are disclosing.

Under a federal rule in effect since 2021, hospitals nationwide have been laboring to post a mountain of data online that spells out their prices for every service, drug, and item they provide, including the actual prices they’ve negotiated with insurers and the amounts that cash-paying patients would be charged. They’ve done so begrudgingly and only after losing a lawsuit that challenged the federal rule.

How well they’re doing depends on whom you ask.

The rule aims to pull back the curtain on opaque hospital prices that may vary widely by hospital for the same service or even within the same hospital. The expectation is that price transparency will boost competition, giving consumers and employers a way to compare prices and make informed choices, ultimately driving down the cost of care. Whether that will happen is not yet clear.

Insurers and large employers are also required to post their negotiated prices with all their providers, under separate rules that took effect last summer.

Hospitals have made “substantial progress,” according to an analysis by the federal Centers for Medicare & Medicaid Services of 600 randomly selected hospitals that was published in the journal Health Affairs last month. The agency looked at whether hospitals had met their obligation to post price information online in two key formats: a “shoppable” list of at least 300 services for consumers, and a comprehensive machine-readable file that incorporates all the services for which the hospital has standard charges. This file should be in a format that allows researchers, regulators, and others to analyze the data.

CMS found that 70{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} of hospitals published both lists in 2022. An additional 12{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} published one or the other. By contrast, the agency’s previous progress assessment in 2021 found that just 27{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} of 235 hospitals had both types of lists.

The 2022 analysis “represents a marked improvement,” said Dr. Meena Seshamani, deputy administrator and director of the Center for Medicare at CMS, in a statement. But she also said the advances are still “not sufficient” and CMS will continue to use “technical assistance and enforcement activity” so that all hospitals “fully comply with the law.”

The American Hospital Association said the CMS assessment demonstrated the progress hospitals had made under very challenging circumstances as they grappled with the covid-19 pandemic.

“These are complicated policies that went into effect in the most complicated time in hospitals’ history,” said Molly Smith, group vice president for policy at the trade association. “And we have seen increases in compliance over the past 18 months.”

Some groups that have looked at the hospitals’ posted price data, though, were less upbeat. In an analysis published last month, Patient Rights Advocate examined 2,000 hospitals’ listings and found that only 489 of them, 24.5{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} of the total, were compliant with all the requirements of the rule. An earlier analysis in August 2022 found that 16{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} met all the requirements.

The advocacy group’s analysis covered not only the two types of lists that CMS looked for but also checked whether the hospitals included required data on specific types of standard charges for every service offered, such as the gross or “chargemaster” charge before any discounts are applied, the discounted cash price, and the negotiated charge by insurer.

Although most hospitals have published files online, too often the data is incomplete, illegible, or not clearly associated with specific health plans or insurers, said Cynthia Fisher, founder and chair of Patient Rights Advocate, which promotes health care price transparency.

“As hospitals continue to post incomplete files with swaths of missing prices, patients are unable to accurately compare prices across hospitals and across plans to make the best health care decisions and protect themselves from overcharges,” Fisher said. Such hospitals were considered noncompliant in the PRA analysis.

The hospital association faulted PRA’s analysis. The contracts that hospitals have with health plans vary substantially from one to the next, and prices are not always based on a simple dollar amount, said Terry Cunningham, AHA’s director of policy. They might be based on a bundle of services or on volume, for example, he said.

“It’s both frustrating and problematic for these other organizations to be weighing in, saying, ‘This cell shouldn’t be blank,’” Cunningham said.

In their 2020 lawsuit, hospitals argued that they should not be required to disclose privately negotiated prices, and maintained that doing so would confuse patients and lead to anti-competitive behavior by insurers.

Last summer, price transparency requirements took effect in the health insurance industry as well, complementing and providing a cross-reference tool for what hospitals have posted. The insurer transparency requirements are even broader than those for hospitals: Insurers and self-funded employers must list every negotiated rate they have with every doctor, hospital, and other health care providers.

Some critics charge that data isn’t user-friendly either. Sens. Maggie Hassan (D-N.H.) and Mike Braun (R-Ind.) sent a letter March 6 to CMS Administrator Chiquita Brooks-LaSure encouraging the agency to take steps to close “technical loopholes” such as large files and a lack of standardization that make it difficult to use the data they’re reporting.

That’s where pricing platforms like Turquoise Health come in. The data becoming available from hospitals and insurers is a vast treasure trove the company is mining to devise user-friendly tools that consumers and businesses can use to discover and compare prices.

In its own analysis of how effective hospital price transparency efforts were in 2022’s third quarter, Turquoise Health found that 55{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} of the more than 4,900 acute care hospitals that posted machine-readable files were “complete,” meaning they posted the cash, list, and negotiated rates for a “significant quantity” of items and services. Twenty-four percent of hospitals were judged to be “mostly complete.” (The analysis didn’t evaluate the second type of posting, the list of shoppable services.)

According to Chris Severn, Turquoise Health co-founder and CEO, the company uses a scoring algorithm of 60 variables to assess how complete a hospital’s file is.

“What you end up with is a more nuanced look at these files that hopefully takes into consideration shades of gray,” Severn said, rather than a simple pass-fail rating.

Regardless of the differences in how the hospital disclosures are evaluated, experts generally agree that CMS should require data be reported in a standardized format for ease of comparison and enforcement. CMS has developed a template, but hospitals aren’t required to use it.

For price transparency to work, enforcement also needs consistent attention, experts say. The Biden administration increased the maximum potential penalty to more than $2 million annually per hospital for 2022. Still, last year CMS penalized just two hospitals for noncompliance even though 30{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} of hospitals didn’t meet the requirement to post both a machine-readable file of prices as well as a shoppable list.

CMS provided technical assistance to many hospitals to help them come into compliance, said Seshamani, and it also plans stronger enforcement actions.

She said the agency will “continue to expedite” the time frame hospitals have to reach full compliance after submitting a corrective action plan, which indicates they have fallen short on some posting requirements. “CMS also plans to take aggressive additional steps to identify and prioritize action against hospitals that have failed entirely to post files,” she said.

KHN (Kaiser Health News) is a national newsroom that produces in-depth journalism about health issues. Together with Policy Analysis and Polling, KHN is one of the three major operating programs at KFF (Kaiser Family Foundation). KFF is an endowed nonprofit organization providing information on health issues to the nation.

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Amazon Takes On Healthcare Worker Burnout

InnovationRx is your weekly digest of healthcare news. To get it in your inbox, subscribe here.

In the wake of the Covid-19 pandemic, there’s one issue that unites hospitals around the globe: health worker burnout. As part of its strategy to help its existing healthcare customers—and woo new ones—Amazon’s cloud division has selected 23 healthtech startups from a pool of 500 applications to participate in its latest healthcare accelerator program focused on workforce issues. “A lot of healthcare organizations—and this is true around the world—are facing financial pressures,” Rowland Illing, chief medical officer and director of international public sector health at Amazon Web Services tells Forbes. “There’s a lot of strain on the system.” As a result, he says, they’re looking to train and retain existing workers, as well as develop new tools to help ease the burden.

Illing says the accelerator is focused on startups that have existing products and are generating revenue, so their main hurdle is how to scale. Selected companies include Momo Medical, Kare and Grapefruit Health (see the full list here). The majority are U.S.- or U.K.-based, which Illing said were the “two most mature markets” for cloud technology. “But we’re scratching the surface in cloud use in healthcare,” he says. “It’s really early.”

Amazon Web Services had around 39{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} market share in the global public cloud market in 2021, according to Gartner, while Microsoft Azure had around 21{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} and Google Cloud was at 7{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f}. AWS has “thousands” of healthcare and life sciences cloud customers but would not disclose them as a percentage of its total cloud customers.

Each startup will get $25,000 in Amazon Web Services computing credits as part of the month-long program. The cloud offers “virtually unlimited access to computing power, analytics, tools, database capabilities and networking around the world,” says Illing. The startups will also get access to mentors, including the American Hospital Association, U.K.’s National Health Service, Humana and Philips, among others.


VCs Still See Opportunity In Medicaid Even As Healthcare Investments Contract

Before the collapse of Silicon Valley Bank rocked the venture capital world, startup funding was already receding from the record highs of 2021—and healthcare was no exception. As consumers and employers tighten their belts, there’s one area of healthcare that tends to grow during market downturns: Medicaid—the government-funded health insurance program for more than 92 million low-income Americans. “It’s a countercyclical bet where there is growth in that segment when there isn’t in other parts of the healthcare value chain,” says Meera Mani, a partner at Town Hall Ventures.

Read more here.


Deals Of The Week

Clinical Trial Tech: Inato, a startup that connects pharmaceutical companies with community-based clinical trial sites has raised $20 million in Series A extension funding in its bid to help expand access to and improve the diversity of clinical trial participants.

Cell Therapy: Japan’s Pharmaceuticals and Medical Devices Agency approved Aurion Biotech’s Vyznova, an off-the-shelf regenerative cell therapy for the eye disorder bullous keratopathy. The company will begin phase 1 trials in the U.S. later this year.

Cancer Progress: GSK announced positive interim results of its phase III trials of Jemperli in conjunction with current standard-of-care for endometrial cancer. The results so far show significant reduction in disease progression and survival compared to standard of care alone.

Narcan OTC: The FDA has approved an over-the-counter formulation of a Narcan nasal spray for the treatment of opioid overdoses, the first such approval it’s made.

Small Molecule Immunotherapy: Covant Therapeutics, a subsidiary of Roivant Sciences, announced anexclusive collaboration with Boehringer Ingelheim for the development of targets against ADAR1 for certain cancers. Covant will receive an upfront payment of $10 million and will be eligible for up to $471 million in milestone payments plus royalties.


Pancreatic Cancer Breakthrough: Discovery Suggests Possible Way To Treat Deadly Disease—And A Drug Already Exists To Do It

Researchers have uncovered an unusual way some cancer cells make nutrients they need to grow, a discovery that could hold the key to starving one of America’s deadliest cancers with a drug we already possess and raising hopes for a powerful new treatment against a disease that is often caught late and has one of the lowest survival rates of any cancer.

Read more here.


Other Healthcare News

Walgreens Boots Alliance quarterly profits fell more than 20{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} to $703 million with the drugstore chain blaming “lower COVID-19 vaccine and testing volumes.”

CVS Health completed its $8 billion acquisition of Signify Health on Wednesday, as it pushes into in-home medical care.

Oscar Health has tapped former Aetna executive Mark Bertolini as its new CEO—the health insurance company, founded in 2012, has grown to 1.1 million members, thanks to Obamacare plans, but has yet to turn a profit.

A bill moving through the Idaho state legislature would criminalize transporting minors to get an abortion without their parents’ consent—if it passes the state senate, Idaho could become the first state to restrict interstate travel for abortion.

Tanzania announced its first-ever outbreak of Marburg virus disease in late March. There’s no approved vaccine or treatment for the Ebola-like disease, which also has been spreading in Equatorial Guinea.

Across Forbes

Diamond Disruptor: Meet The Nerdy King Of Bargain Bling

Sam Bankman-Fried’s Legal Defense Is Being Funded With Alameda Money He Gifted His Father

SVB’s New Owners Are Quietly Building A Banking Empire

What Else We are Reading

How Cigna Saves Millions by Having Its Doctors Reject Claims Without Reading Them (ProPublica)

Pressure is building on pharma and biotech companies to take climate action (STAT)

Banning Noncompete Contracts for Medical Staff Riles Hospitals (Kaiser Health News)