China releases ‘landmark’ document on ethics reviews of life sciences, medical research involving humans

China releases ‘landmark’ document on ethics reviews of life sciences, medical research involving humans

Chinese scientist He Jiankui presents his gene-editing experiment at the Second International Summit on Human Genome Editing in Hong Kong on Wednesday. Photo: AFP

China released a national regulation on ethics reviews of life sciences and medical research involving humans, which experts take as a “landmark document” since the illegal human genome editing case by the controversial scientists He Jiankui in 2018.

Life sciences and medical research involving humans includes research activities using humans’ biological samples and data to conduct research activities involving reproduction, growth, development and aging through physical, chemical, biological and traditional Chinese medicine methods. 

It also covers experiments on human bodies with new technologies or new products, according to the regulation released on the website of the National Health Commission (NHC) on Monday.  

Compared with the previous version released in 2016, the newly revised regulation expands the application scope from only medical institutes to colleges as well as scientific research institutes and clarifies regulatory duties of various related authorities, according to an explanation on the document by the NHC.

It also allows institutes that had not set up ethics review commissions to entrust a capable commission to conduct ethics reviews. Companies can also entrust a capable commission to conduct ethics reviews or supervision of a project. 

The new regulation also gives detailed rules on the specific steps of the ethics review.    

It stressed that ethics review commissions should regularly conduct reviews of life sciences and medical research involving humans and organize educating and training sessions for related research fellows, students and management personnel. 

Ethics reviews should also be carried out timely under an emergency situation. For example, during the outbreak of an epidemic, such reviews should be conducted within 72 hours, with equal requirements in normal times. 

Life sciences and medical research involving humans should be of scientific and social value and special attention should be paid to the research concerning fertilized eggs, embryos, fetuses or those that could be affected by assisted reproductive technology, the regulation noted.  

Experts reached by the Global Times hailed the new regulation, saying it is a “landmark regulatory document” since the illegal human genome editing case by the controversial scientist He Jiankui in 2018. 

In 2018, He, a genome-editing researcher at the Southern University of Science and Technology of China in Shenzhen, Guangdong Province, shocked the world as he claimed to have created the world’s first genetically modified humans.

He was sentenced to three years in prison in December 2019 for illegally conducting human embryo gene-editing intended for reproduction. He was reportedly released from prison in April 2022.

He made a high-profile comeback in early February as he attended an academic seminar focusing on the social values of CRISPR technology, sparking heated discussion on the ethical issues of scientific development. 

He caught public attention again last week as the Immigration Department of Hong Kong Special Administrative Region on February 22 invalidated the Top Talent Pass visa it had issued to He for “false statements” less than a day after He told media he had obtained the visa. 

What Makes Health Care Workers Stay in Their Jobs?

Ask leaders of health care organizations about their top three challenges for the year ahead, and many answer, “Workforce, workforce, and workforce.” These leaders go on to say that they are struggling to recruit and retain caregivers of all types, that the costs are breaking their budgets, and that morale is at historic lows. As a direct result, every type of performance is suffering: financial, safety, and overall quality, including the patient experience.

With an air of desperation, organizations are trying many tactics, including awarding bonuses for signing, staying, and referring new recruits. They are implementing programs to reduce burnout like mindfulness training and investing in AI and other technologies that reduce administrative burden. All of these tactics to improve compensation and mitigate the deadening aspects of work have merit, but organizations should not rely upon them to create the loyalty and resilience needed for excellence in health care.

Our data on hundreds of thousands of physicians, nurses, and other caregivers in the United States shows that pride in their work and loyalty to their colleagues are the strongest correlates of their readiness to stay with their organization and continue showing up for work. Competitive pay and other support options are essential to recruiting caregivers, of course, but organizational culture, including a commitment to excellence, is what makes them stay.

Improving organizational culture is a leadership challenge that is more complex than finding the money to increase compensation or correcting the problems that cause unhappiness. After all, in life in general, happiness is something beyond the absence of unhappiness. The same is true in health care. For example, “service recovery” programs that quickly address patients’ complaints can mitigate their ire, but lack of ire does not equate to loyalty. Similarly, organizational responses to caregivers’ pain may prove that the leaders care, but it doesn’t mean that the caregivers will keep showing up and doing whatever it takes to meet their patients’ needs.

What does drive loyalty and resilience among caregivers? As is true in other industries during these difficult times, getting back to basics is crucial — and in health care that means focusing organizational culture on the noble cause of reducing patients’ suffering and then supporting caregivers in that work. Our data demonstrates that this is not wishful thinking; it is an operational imperative.

For example, we have analyzed the drivers of loyalty for 410,000 health care employees during the pandemic. In these analyses, we examine factors that correlate with employees’ expressing strong agreement with these two statements: “I would stay with this organization if offered a similar position elsewhere” and “I would like to be working at this organization three years from now.” For both metrics, there has been a marked decline across the country from 2020 to 2022 (on a 1-5 scale, from 4.15 to 4.00 for the first statement and from 3.93 to 3.78 for the latter).

But the patterns of change have not been the same in every organization and for every job type. There has been a “spreading of the pack,” with greater variation than in the past in measures of workforce engagement between organizations doing well and those doing poorly. The data suggests that leadership matters as never before — not just at the C-suite level but also at the front lines where managers really determine how organizational culture feels for employees. For example, there can be vast differences in how caregiver morale in two patient care units that are physically adjacent to each other but have different nurse managers.

Whatever variation exists among managers, there seems to be remarkable consistency in what matters to the people working for them. In our analyses, for all types of health care personnel, their organizations’ commitment to quality and patient-centered care was among the top drivers of their likelihood to stay. When employees gave their organization low ratings on these issues, they were more than six times as likely to say they were preparing to leave. These issues were important to security guards, maintenance, and clerical personnel as well as clinicians.

That finding may seem surprising at first glance, but as one hospital executive said to us, “It makes perfect sense. When patients feel mistreated, they don’t yell at the doctor very often; they take it out on the clerks and security guards. But when patients have a great experience, the clerks and security guards get to bask in the glow – and that makes them want to stay.”

For physicians, the top factors that correlated with their expressed likelihood of staying were whether they like their work, feel the organization is making good use of their skills, and the organizational culture. For example, if physicians felt that the organization did not have an inclusive culture, that increased their risk for considering leaving 5.5-fold. Competitive compensation packages are presumably critical to recruiting physicians, but culture is essential to retaining them.

Press Ganey’s data is completely consistent with the findings of a study of 20,627 physicians and advanced practice clinicians in 120 large U.S. health care organizations by Mark Linzer and his colleagues that was published last November in the JAMA Health Forum. It found that intent to leave had increased from 24{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} in 2019 to more than 40{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} in 2021 but identified several factors that mitigated the risk of burnout. In multivariate regression analyses, positive factors included feeling valued, good teamwork, and having values that are aligned with those of leaders.

Our data for physicians, nurses, and all types of personnel demonstrate a halo of positive effects that accompany these sources of caregiver pride. For example, these measures of overall “engagement” with the organization also correlate strongly with measures of safety culture, such as their confidence in the organization’s commitment to preventing and reporting adverse events — and those safety culture measures are associated with lower rates of safety events. In short, data confirms that excellence in all performance areas that drive business success are intertwined: patient experience, quality and safety, and the engagement of the workforce.

The implications of these findings for health care leaders are that they, of course, must listen carefully to grasp what issues are causing employees’ pain and fear and try to address them. But leaders must also listen to understand their employees’ hopes for what their work means to them and reinforce the aspirations that brought their employees to health care to begin with.

To do that, leaders must be clear about their values, their commitment to safety, the reduction of suffering, and a culture of respect and inclusion. They must prove their authenticity by committing to measuring how things are going on these issues, being transparent with the findings, and using them to improve. The result will be greater workforce loyalty and resilience, which will translate to better performance of all types.

Trainerize Powered by ABC Fitness Voted as the #1 Platform of 2022 by Personal Trainers and Coaches

G2, the largest tech marketplace, named Trainerize the leading software for personal trainers for each season in 2022

VANCOUVER, BC, March 2, 2023 /PRNewswire/ — Trainerize, the fitness coaching software empowering personal trainers and fitness businesses to better engage with their members, is delighted to announce its recognition as the best personal training software from the community, marketplace, business and review platform, G2 all throughout 2022.

Trainerize Powered by ABC Fitness Voted as the #1 Platform of 2022 by Personal Trainers and Coaches

Trainerize

Trainerize was the winner of G2’s award for Best Personal Training Software in every season in 2022, claiming the #1 position in Winter, Spring, Summer, and Fall.

The criteria for this particular recognition consists of review scores from the G2 user community and data aggregated from online sources and social networks. The points process takes into account how well the fitness software can empower fitness professionals to keep track of client information, create training and nutrition plans, schedule meetings/training sessions, and easily manage online client payments.

Trainerize exceeded all of the necessary criteria and proved to be an excellent solution for coaches to manage client fitness, nutrition and habit programming in one place. In addition, Trainerize aids its users with keeping track of their clients’ progress and increasing client engagement.

Throughout 2022, the Trainerize platform was also awarded with several other badges from G2 under various categories, including: Best Usability, Best Results, Best Relationship and Users Most Likely To Recommend.

Speaking after G2’s Winter award winners were announced, Trainerize Platform President, Sharad Mohan said, “for Trainerize to be recognized as a Leader in Personal Training Software is not only gratifying, but extremely motivating. This award is based on real-life consumer reviews and feedback, which not only makes it so much more meaningful, but also tells us that what we’re doing at Trainerize is working. So we’re going to keep doing it—and more. We’ll keep delivering the kind of platform personal trainers and fitness businesses both want and need—and that their clients and members love using.”

About Trainerize

Trainerize is a client engagement mobile app and software that allows fitness businesses and fitness professionals to expand their reach beyond their physical spaces, better connect with clientele, build meaningful relationships, and digitize the training experience. Fitness businesses use Trainerize to boost member engagement through digital services as well as attract new members by tapping into the market of online training. To learn more, visit www.trainerize.com.

About ABC Fitness Solutions

ABC Fitness (ABC) is the market leading software and services provider for fitness businesses globally. Building upon a legacy of excellence, ABC enables fitness operators of all sizes, anywhere in the world to transform their vision of fitness into reality. Whether a boutique studio, international franchise, regional club chain, local gym, or personal trainer, ABC provides the industry insights, technology, and innovation to partner for growth long-term. Our club management solutions simplify business operations while unveiling opportunities for further development and evolution. We are the only software provider to be able to support fitness businesses from conception all the way through to high-scale growth internationally, delivering reliability and quality at scale.

Founded in 1981, ABC has grown its global capabilities and expanded its integrated solution suite through the development of best-of-breed platforms such as IGNITE, Trainerize, Glofox, EVO, as well as other leading solutions. ABC helps over 35 million members around the world and processes over $8.8B+ in payments annually for 24,000 clubs in over 92 countries. ABC Fitness Solutions is a Thoma Bravo portfolio company; a leading private equity firm focused on investing in high-growth software and technology companies.  Learn more at abcfitness.com or thomabravo.com.

Media Contact
Laura Dunlop
Marketing Director, Trainerize
778.953.2489
354793@email4pr.com

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Trainerize – Best Coaching App

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Nonprofit Chosen BCS aims to ensure all have access to needed medical equipment

BRYAN, Texas (KBTX) – In a recently leased warehouse on Texas Avenue in Bryan, Chosen BCS, a faith-based, community-oriented organization is working to be a lifeline to those in need of durable medical equipment.

The nonprofit is set to open in the next month and has already started to collect new and gently used medical equipment like wheelchairs, canes, walkers, hospital beds, and more, all to distribute to people in need.

Chosen is an international ministry based out of Erie, PA with local distribution and collection sites across the country.

Longtime Brazos County resident Sara Hadley is the director of Chosen BCS Pavilion Texas. Once operational, she says the ministry aims to bridge the gap for people needing medical supplies.

“Medical equipment is essential for the care and well-being of many individuals. Unfortunately, many people cannot afford it or have limited access to it,” says Hadley. “Chosen seeks to offer a beacon of hope and lifeline to those who need medical devices to enable them to live their best life.”

“There are no boxes to check, no income or insurance requirements, or timelines to fulfill. Locally, we distribute everything from gauze to hospital beds to anyone who expresses a need for our staff,” said Hadley.

The Brazos County District 2 Volunteer Fire Department recently made the first donation to Chosen BCS.

“Excited to see Chosen B/CS take what we were doing with our medical supply loan closet to the next level to serve the entire county, and then some,” the district said in a social media post.

Hadley says the hearts this team has for God and His people is the most inspiring and the driving force behind bringing this ministry to the Brazos Valley.

For more information on Chosen BCS and how you can get involved call 979-204-1104

Equipment includes:

  • Canes
  • Crutches
  • Walkers
  • Bedside Commodes
  • Toilet Rails
  • Bed Canes & Bed Rails
  • Wheelchairs
  • Transport Chairs
  • Pulmonary Walkers
  • Knee Scooters
  • Reclining Wheelchairs
  • Shower Chairs & Transfer Benches
  • Toilet Risers
  • Hospital Beds & Mattresses
  • Bedside Tables & Bed Trays
  • Nebulizer Machines and Accessories
  • Incontinence Supplies
  • Blood Pressure Monitors (Home Use, Non-Mercury)
  • Hoyer Lifts, Hoyer Slings, & Sara Lifts
  • Feeding Bags and Tubing
  • Medical Supplies (Gloves, Wipes, Etc.)
  • Diabetic Supplies
  • Wound Care Supplies (Bandages, Gauze, Etc.)
  • Shoes
  • Step Stools
  • Transfer Boards
  • Shower Grab Bars
  • Tub Rails
  • Sock Aids & Shoe Horns
  • Dressing Sticks
  • Reacher/Grabbers
  • Leg Lifters
  • Oxygen Concentrator
  • O2 Carriers
  • Humidifier Machines
  • Portable Ramps
  • Lift Chairs
  • Cushions (Wedge, Egg Crate, Donut, Wheelchair)
  • Colostomy Supplies
  • Other (Please Contact Prior to Dropping Off)

Mediterranean lifestyle, not just diet, may greatly improve health

Mediterranean lifestyle, not just diet, may greatly improve health
Credit: Pixabay/CC0 Public Domain

Much is known about the heart-health benefits of adopting a Mediterranean-style diet, with its heavy focus on whole grains, fruits, vegetables, fish and healthy oils. But what about the rest of the Mediterranean lifestyle?

Short of lounging on the beaches of southern Italy or an island in Greece, could adopting the focus on relaxed, familial dining, afternoon naps and strong communal bonds also improve health?

A group of researchers explored what would happen if middle-aged and older British adults—who live about 1,500 miles northwest of the Mediterranean Sea and its convivial way of life—adopted not just the dietary but also the physical activity and social habits of their southern neighbors. And they found that the more they adhered to this lifestyle, the lower their risk of dying from cancer, cardiovascular disease and other health conditions.

The findings, presented Feb. 28 at the American Heart Association’s Epidemiology, Prevention, Lifestyle and Cardiometabolic Health conference in Boston, are considered preliminary until full results are published in a peer-reviewed journal.

“This study suggests that adopting a Mediterranean lifestyle adapted to the local characteristics of non-Mediterranean populations is possible and can be part of a healthy lifestyle,” said the study’s senior researcher, Mercedes Sotos-Prieto, an assistant professor in the department of preventive medicine and public health at the Autonomous University of Madrid, Spain. She also is an adjunct professor at the Harvard T.H. Chan School of Public Health in Boston.

Prior research has shown the Mediterranean-style eating pattern helps protect against cardiovascular disease, lowering the risk for heart attacks and strokes. In this latest study, researchers analyzed the impact of other Mediterranean lifestyle factors—including physical activity, rest, social habits and conviviality—on 110,799 middle-aged and older adults living in England, Scotland and Wales.

Participants were drawn from the UK Biobank, a multi-center, population-based study of people ages 40 to 75 who were free of cancer and cardiovascular disease when they enrolled between 2009 and 2012. They were followed until 2021.

A 25-point MEDLIFE index was used to score their adherence to the Mediterranean lifestyle. The index was broken down into three blocks: Mediterranean food consumption (12 points), which looked at what people ate; Mediterranean dietary habits (7 points), which looked at additional factors such as whether they snacked, added salt to their meals or preferred whole grains to refined grains; and other lifestyle factors (6 points).

The last block included questions on whether people ate meals with family and friends (conviviality); engaged in physical activity with others, for example by going on walks together; how often they met with family and friends (social habits); and how much sleep they got, both at night and through naps (rest).

After a median follow-up time of 9.4 years, death records were used to compare death rates for cancer, cardiovascular disease and all other causes between those with higher and lower MEDLIFE index scores. The analysis showed the more people adhered to the Mediterranean lifestyle, the lower their risk of dying from cancer or from any cause.

Specifically, compared to those with the lowest MEDLIFE index scores, adults with the highest adherence to the Mediterranean lifestyle had a 29{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} lower risk of dying from any cause and a 28{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} lower risk of dying from cancer. Higher scores for each of the three blocks of the MEDLIFE index were associated with lower cancer and all-cause death risks. Higher scores for the third block, related to lifestyle activities, also were associated with lower cardiovascular death risks.

The study highlights the important roles community and social engagement play in good health, said Marie-Pierre St-Onge, an associate professor of medicine and director of the Center of Excellence for Sleep and Circadian Research at Columbia University in New York City.

“The Mediterranean lifestyle involves interactions with others,” she said, a component that is particularly important for people as they age. Studies have shown social isolation may increase a person’s risk of having or dying from a heart attack or stroke.

The findings emphasize why “we should be paying attention to other aspects of lifestyle, beyond just physical activity,” said St-Onge, who was not involved in the study. “Maybe we need to look at more and more of these social factors.”

One thing the study did not explore and would be of interest in future studies is the impact of stress, she said. “When you think about the Mediterranean lifestyle, you think about living at a slower pace, but this study does not seem to capture that.”

More information:
MP08—Association of a Mediterranean Lifestyle With All-Cause and Cause-Specific Mortality: A Prospective Cohort Study From UK Biobank. www.abstractsonline.com/pp8/?_ … 825/presentation/200

Provided by
American Heart Association


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Inside America’s youth mental health crisis

Kids in the U.S. and around the world are in crisis. 

More than 60{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} of children with depression don’t get any mental health treatment, according to Mental Health America. Pair that statistic with the fact that about 80{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} of the United States has a severe shortage of child psychiatrists, and the picture becomes clear: there is a growing mental health crisis in the United States and beyond. 

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That’s why CBS News and local CBS-owned television stations spent more than six months exploring the sources of the problem, as well as solutions across the country that could address it. This is a collection of the reporting by CBS journalists, committed to the well-being of our kids.  

Documenting kids’ personal struggles

“Bring darkness into the light,” said filmmaker Noemi Weis. 

That’s the goal of her documentary, “Connecting the Dots,” which features young people from around the world candidly talking about their struggles with mental health and the need to be supported. 

“We need to listen in a way that is with open eyes and with providing a safe space, providing no judgment,” Weis told CBS News.  “As much as we believe that we are in a world where we are all connected, the disconnect is huge. The isolation, the loneliness needed to be addressed.” 

CBS News licensed the documentary for an exclusive release nationwide on its streaming platforms Wednesday night. The film will be available to view on demand following the streaming event.

The filmmaker created facilitator guides, in partnership with UNICEF, for youth, parents, educators, mental health professionals, and others to watch the documentary and discuss it.

Seeking mental health help 

If you or someone you know is in crisis, get help from the Suicide and Crisis Lifeline by calling or texting 988. 

In addition, help is available from the National Alliance on Mental Illness, or NAMI. Call the NAMI Helpline at 800-950-6264 or text “HelpLine” to 62640. There are more than 600 local NAMI organizations and affiliates across the country, many of which offer free support and education programs. 

Read more from CBS News and local stations

CBS News will continue to update this page as we publish more stories about youth mental health in the coming days.

Fearing Daniel might harm himself, his parents took him to the only place they could: the emergency room. After seven days in the ER, Daniel was discharged; hospital staff felt he was no longer in danger. His parents disagreed. Read more

Young people are increasingly turning to social media platforms like TikTok to diagnose their mental health struggles and often getting misinformation. A California psychology professor has gained a million followers on TikTok by debunking wellness advice that could do more harm than good. Read more

Jamie Howard, senior clinical psychologist at the Child Mind Institute, joins “CBS Mornings” to discuss the youth mental health crisis and shares tips on how parents can have an open conversation with their teens about mental health and social media. Read more  

In a city with near daily gun violence, the sound of police sirens and the roar of emergency vehicles often become a part of life in some high-crime areas, leaving the ear-piercing noise nearly ignored. For those young people who are becoming more of the victims of gun violence, their trauma seeps through and is ever-present. Read more

A tragedy in the San Francisco Bay Area was the spark a group of California teens needed to do something about breaking the stigma associated with youth mental illness and how to react in an emotional crisis. Read more

Taking a break from social media – even a short one – can have a powerful impact on the self-esteem of young women. Researchers at Colorado College conducted a study with teenage girls, and found that just three days off social media led to significant improvements in body image. Read more

On a piece of land on Chicago’s West Side, the community group BUILD Inc. has done just that. “We’ve got a whole new building,” said David Rodriguez, a BUILD member. “We’ve got a second floor finally.” Read more

Behind the hustle and bustle of Manhattan, and tucked away beneath another busy school day, there’s a break — 45 tranquil minutes in the basement of New Design High School on the Lower East Side.

It’s where kids forget about calculus and chemistry and clear their minds through yoga. Read more