Patients losing out amid slump in NHS clinical trials, warn top clinicians | Medical research

The state of clinical trials in the NHS is “much worse than it has been in years” with patients losing access to cutting-edge cancer and dementia treatments, one of the UK’s most senior clinicians has warned.

Sir John Bell, the regius professor of medicine at the University of Oxford and a government life sciences adviser, said the UK’s approach needed “a full overhaul, top to bottom” to prevent a collapse in the number of clinical trials being conducted in the NHS.

“I don’t think there’s any doubt that companies are choosing not to evaluate their drugs in the UK,” he said. “The risks [to patients] are much bigger than have been alluded to.”

The intervention comes after the government launched an independent review led by the former health minister James O’Shaughnessy into why the NHS had seen a 44{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} drop in participants recruited to commercial clinical trials in the past five years. The UK is rapidly losing ground to countries such as Spain, Poland and Australia, falling from fourth to 10th internationally for phase III trials.

Prof John Bell.
Prof John Bell says patients get access to groundbreaking treatments and the NHS makes money from conducting commercial trials. Photograph: Sophia Evans/The Observer

Reduced access to trials is particularly concerning for patients with limited routine treatment options, such as the roughly 3.5 million people living with rare diseases and patients with dementia and advanced cancer.

Beyond clinical benefits, the NHS makes money from conducting commercial trials. “You get the drugs for free, you get the treatment for the control arm for free, the NHS rides for free for everyone in the trial and pharma pays pretty well to get these trials done,” said Bell.

However, Bell said bureaucracy that had been simplified during the pandemic to fast-track trials had “crept back into the system and ossified” and the overstretched NHS workforce was losing capacity for research. “The system needs a pretty serious revamp,” said Bell. “[The government] is not going to fix this by just turning the handle a bit harder.”

Official figures show just 52{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} of trials in the NHS are running to schedule – a significant improvement in recent months but still some way from the target the Department of Health has set for 80{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} trials being delivered to time and target by June.

The department has directed funders to shut down any trials that have missed their target to start recruiting by more than 90 days, with one in 10 trials being monitored under its Reset Research programme set to close prematurely. Five hundred trials have been closed under the initiative since May last year.

Other senior clinicians also raised concerns. Prof James Rowe, a senior dementia researcher at the University of Cambridge and consultant neurologist, said the UK’s lengthy approvals process could leave clinicians and their patients frozen out of international multicentre trials.

“If it’s going to take you 12 months to get started in the UK, by the time you get the green light the trial is effectively closing for recruitment internationally. It could be futile to begin the work to set up,” he said.

“It’s a great pity as there’s fantastic progress in the dementia world. There are 300 clinical trials for dementia worldwide. The UK should be at the forefront of this, not putting up barriers.”

Prof Paul Stewart, the vice-president (clinical) of the Academy of Medical Sciences and of the University of Leeds, said research tended to be viewed as a luxury rather than an integral part of the NHS’s mission.

“As I reflect on my 40-year career in the NHS, there have always been challenges, but now the crisis has come to a head in terms of a research capacity issue. The current environment is extremely challenging,” he said.

Dr Ian Walker, of Cancer Research UK, said the pandemic continued to “cast a long shadow” over clinical research. “As backlogs for diagnosis and treatment grow, NHS staff face more pressures and protecting time for research is increasingly difficult,” he said. “If this pattern continues, it means slower progress towards brand new treatments for cancer.”

George Freeman, the minister at the Department for Science, Innovation and Technology, said: “Commercial clinical trials are absolutely vital to both our UK life sciences sector and widening NHS patient access to innovative medicines all across the UK. The UK has traditionally been a strong global location for trials, as demonstrated most recently through the groundbreaking Covid recovery trial which was set up in record time and was the world’s largest randomised controlled trial for Covid-19.

“However, our life sciences sector has reported a 44{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} fall in recruitment of patients to commercial clinical trials between 2017 and 2021 – so it is vital that we act to rebuild competitiveness.”

Britain’s NHS was once idolized. Now its worst-ever crisis is fueling a boom in private health care


London
CNN
 — 

Tens of thousands of nurses and nearly 12,000 ambulance workers went on strike Monday over pay and working conditions in the biggest walkout in the 75-year history of Britain’s National Health Service (NHS).

Escalating industrial action comes after years of falling wages, stretched budgets and staff shortages that have left the NHS in a state of crisis, with waiting times for treatment at a record high. At the same time, an aging population needs its services more than ever.

That unhappy mix is fueling a boom in demand for private health care from a much broader swathe of the UK population than ever before — a fundamental shift for a nation with one of the world’s best-known universal health systems.

“Our providers are telling us that people are going private, many for the first time, and the key factor driving that is the challenge in accessing NHS care,” said David Furness, policy director at the Independent Healthcare Providers Network, an industry body for private healthcare companies.

Nurses of the University College Hospital protest in London on  Monday, February 6, 2023.

At the end of November, a record 7.2 million patients in England were waiting for non-urgent medical treatment on the NHS, known as “elective” care. This spans diagnostic tests and scans, procedures such as hip and knee replacements, but also cardiac surgery, cancer treatment and neurosurgery.

More than half of those on the list had been waiting up to 18 weeks and about 400,000 patients had been waiting more than a year, according to data from NHS England.

To avoid joining a waiting list, more and more people are paying for their own private medical care or taking out health insurance.

In the second quarter of 2022, the number of patients paying directly for private hospital care increased 34{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} compared with the same period in 2019 to reach 67,000, according to the Private Healthcare Information Network, which collects data on UK private healthcare.

The figures revealed a 184{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} jump in the number of people paying privately for hip replacements over that period, a 153{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} increase in self-pay for knee replacements and a 42{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} rise in private cataract surgery.

To keep up with growing demand for their services, private health care providers are expanding at a rapid clip.

US group Cleveland Clinic plans to open its third UK facility in London later this year, adding to the 184-bed hospital and the six-floor clinic it opened in the capital city in 2021 and 2022 respectively.

HCA Healthcare

(HCA)
, another American group, which has over 30 facilities in London and Manchester, will be opening a £100 million ($120 million) private hospital in Birmingham — the second biggest UK city — later this year.

London Bridge Hospital, one of the UK's largest private hospitals operated by HCA Healthcare.

And Spire Healthcare, one of the largest private hospital groups in the United Kingdom, is adding new clinics, theaters and beds around the country as it races to keep up with demand.

CEO Justin Ash estimates that the market for private health care in the United Kingdom has doubled since before the pandemic to 15 million people.

“Our biggest single challenge is how do we treat the numbers of patients coming towards us,” he told CNN.

The group plans to develop two new clinics in 2023, which are quicker to build than hospitals and are designed for procedures that don’t require overnight stays — for example, those in ophthalmology, gynecology and dermatology.

Spire is also pushing into primary care services, citing demand for face-to-face appointments with general practitioners. In December, it acquired The Doctors Clinic Group, a network of 22 private GP clinics with a strong presence in central London.

Ash said that appetite for private health care spans a much broader set of ages and incomes than in the past.

“This is not the super-rich. This is ordinary people who are choosing to go private, and that is a shift,” he said.

One such patient is Emma Freeth, a website administrator. She decided to take out private medical insurance after waiting nine months to see a specialist on the NHS.

“That’s what really triggered it: the idea that I just want to be able to get the help when I need it, rather than having to wait and wait and wait,” she told CNN. “If I was in pain or discomfort this would be a real problem,” she said of her thoughts at the time.

In November, Freeth, 58, and her 55-year-old husband Peter, a photographer, took out medical insurance in their personal capacity for the first time in their lives.

Their story is mirrored in data from health insurers. Bupa added 150,000 new UK health insurance customers in 2022, while rival VitalityHealth has seen a 20{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} rise in customers over the past year to more than 900,000.

“We expect the growth we have seen in health insurance uptake to continue in 2023,” said Neville Koopowitz, CEO of Vitality UK.

“This is because people are undoubtedly turning to private healthcare to ensure they have access to high-quality care, quickly, if they were to get ill,” he added.

Nursing staff and supporters march from University College Hospital to Downing Street on January 18, 2023 in London, England.

The Freeths, who are self-employed, said minimizing time off work with ill health was a major factor in their decision making, particularly given long wait times for appointments on the NHS.

According to the Office for National Statistics, record numbers of Brits are leaving the workforce due to long-term sickness, a problem it partly ascribes to long wait times for NHS treatment.

This is an issue of growing concern to employers. Recent polling by Savanta of more than 1,000 businesses on behalf of the Independent Healthcare Providers Network found that over half are worried that rising NHS waiting times may result in employees taking long absences or permanently leaving work due to sickness.

And one in five said they were considering offering private medical insurance to their employees in the coming year.

With the NHS estimating that it will take years for wait times to fall, the demand for private health care in Britain is set to keep growing.

Longer-term, there are questions about whether the NHS is sustainable in its current form, offering comprehensive free health care to all funded purely by taxes, particularly against the backdrop of an aging population and strained government finances.

The NHS is already the largest single item of public expenditure in Britain, according to the Office for Budget Responsibility, with ONS figures showing that healthcare spending amounts to around 12{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} of GDP.

Some experts worry that moving away from a universal NHS would lead to a two-tier health system where people with means pay for private care, enabling them to go back to work and resume normal life more quickly than those who are less well-off and forced to rely on constrained public services.

“The risk is less a sudden privatization and more an emergence of something resembling the English education system — where the very best education is so often conditional on ability to pay,” researchers at the Institute for Public Policy Research, a think tank, wrote in a report last year.

“If this were to become the new normal… it would worsen overall health and widen inequality,” they added.

But Ash of Spire Healthcare has a less dystopian view of the future. “We’ve clearly moved into a world in which we’re all NHS patients but have episodes of private care,” he said.

That’s “a million miles from a US system,” he added. There is no universal health care in America and most people have private health insurance because health care is very expensive.

“There is huge commitment to the NHS. You cannot underestimate that,” Ash said.

NHS medtech strategy to boost access to safe, effective and innovative medical devices

People across the British isles are set to advantage from accessibility to safe, helpful and innovative products and medical gadgets as portion of the initial ever health care know-how (‘medtech’) technique released today.

The blueprint for boosting NHS medtech will emphasis on accelerating obtain to progressive systems, this sort of as the newest generation of house dialysis equipment that permit clients to regulate their personal wellness at residence and in their working day to working day lives.

It also sets out actions which need to have to be taken to make certain sufferers can access secure, productive and innovative technological know-how by means of the NHS, which can help diagnose, take care of and supply care much more rapidly, releasing up clinician time. The NHS spends £10 billion a yr on medtech together with syringes, wheelchairs, cardiac pacemakers and health care imaging machines this sort of as x-ray machines.

Making on learnings from the Covid-19 pandemic and the fast growth of health care systems throughout that time these as lateral flow exams and ventilators, this system will be certain the suitable item is out there at the right value and in the correct position. As a end result, sufferers will carry on to have obtain to significant-excellent treatment, along with enhanced patient safety and health and fitness outcomes.

The approach aims to supply worth for revenue, working with the most current info on the success of new technology to guarantee price ranges are realistic for the overall health method. It will also help establish resilient supply chains and make certain the British isles is geared up for future pandemics, just as demand for technological innovation like syringes and ventilators swiftly enhance through the pandemic.

Applying medtech properly will be vital in minimizing waiting lists for therapy triggered by the pandemic as it has the potential to speed up diagnosis and produce new and improved methods to deal with and help clients. For case in point, Covid-19 demonstrated the relevance of quick and exact diagnostic testing and genome sequencing to procedure and share effects and property lateral flow tests confirmed the probable for greater use of diagnostics outside of formal medical options, to aid earlier analysis and no cost up staff time.

Minister of Point out for Wellness Will Quince explained:

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The UK’s impressive spirit shipped revolutionary know-how during the pandemic – from Covid exams and ventilators – and we want to harness this in endorsing chopping-edge healthcare developments to strengthen affected individual care.

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The NHS spends all-around £10 billion a yr on health-related technological know-how and I’m hunting forward to operating with industry to use this as we aim on lessening hospital stays, improving analysis, protecting against disease and releasing up team time.

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This new medtech approach will assistance develop a sustainable NHS with people at the centre so men and women can carry on to accessibility the correct care at the appropriate time.”

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The important aims of the technique are to:

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  • Improve the provide of the ideal gear to provide higher resilience to wellness care worries, these kinds of as pandemics, and boost NHS general performance by means of modernized technological know-how which will permit speedier analysis, remedy and ultimately discharge to absolutely free up medical center beds.
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  • Inspire formidable, innovative investigation to safe the UK’s posture as a world wide science superpower and draw in critical financial commitment for the United kingdom financial system and produce careers throughout the region. In 2021, there were now all around 60 unique investigation courses supporting progressive systems, symbolizing more than £1 billion of funding.
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  • Improve comprehension and awareness of medtech by clinicians which will guide to additional informed getting on new goods and provide improved value for taxpayer dollars and greater solutions for clients.
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  • Make on the Lifestyle Sciences Eyesight to boost collaboration between the NHS, the Countrywide Institute for Health and fitness and Treatment Excellence and the Medicines and Healthcare solutions Regulatory Agency as an innovation associate to make sure sufferers can obtain the correct items safely.
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The implementation system to provide on this system will be revealed later this year and will involve a assessment of the £1 billion put in on appliances in principal treatment, new comparison instruments to allow much better conclusion earning when buying which realize the finest final results for people, and collaboration with market to assure availability of crucial solutions to keep patients safe.

Dr Timothy Ferris, nationwide director for transformation at NHS England said:

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Clinical technological know-how has an huge function to play in benefitting sufferers now and in the future.

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The value of medtech was designed clear in the course of the Covid-19 pandemic and as the NHS moves by way of its recovery, it will enjoy a essential job in addressing the issues we deal with.”

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Dr Sam Roberts of the National Institute for Overall health and Care Excellence mentioned:

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It is necessary that clinicians and patients can obtain the most impactful and price-productive clinical systems, even though MedTech corporations want to be confident that they are creating items which fulfill the requires of clients and the NHS.

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This technique sets out a apparent vision for the long term. Awesome is psyched to be element of the delivery of this vision, performing with our partners to even further build earth leading processes to provide a sustainable pathway for medical technologies, from innovation to implementation”.

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Peter Ellingworth of the Affiliation of British HealthTech Industries claimed:

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ABHI welcomes the publication of the DHSC MedTech Tactic, and the recognition it provides to the worth of HealthTech in supporting the NHS to provide exceptional treatment for men and women in the British isles. HealthTech performs a beneficial position in enabling enhanced outcomes as a result of modifying client pathways as nicely as efficiency and efficiency gains.

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It is critical that this tactic supports the ambition of the Existence Sciences Eyesight to develop an remarkable enterprise atmosphere for HealthTech corporations. We glimpse ahead to working intently with the Directorate in the implementation the method.”

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This technique follows action to slice NHS waiting instances as just one of the government’s major 5 priorities, backed by up to £14.1 billion of health and social care funding accessible for the following two a long time, on prime of history funding and the publishing of a new urgent and unexpected emergency treatment recovery program.