Healthy Lifestyle Could Prevent IBD Cases

New analysis indicates that inflammatory bowel illness (IBD) possibility could be moderated by a healthy lifestyle.

Sustaining a nutritious life-style may possibly avert up to 60{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} of inflammatory bowel disorder (IBD) circumstances, in accordance to new analysis.

Researchers at Massachusetts Common Medical center and other health corporations revealed the huge intercontinental study on IBD, which consists of Crohn’s condition and ulcerative colitis (UC), in the journal Gut.1

Beforehand printed investigate has connected IBD danger with several life-style variables, but it is not very clear if adopting and maintaining a healthful life style could possibly decreased the risk of acquiring the situation in the initially put, the BMJ (British Medical Journal) claimed in a information launch.2

The scientists reviewed data from the Nurses’ Wellness Study (NHS), NHSII, and the Health Gurus Adhere to-up Research (HPFS). The NHS enrolled 121,700 female nurses aged 30–55 decades from 11 US states in 1976, whilst the NHSII analyze, proven in 1989, monitored 116,429 woman nurses aged 25–42 decades from 15 US states. The HPFS incorporated 51,529 male medical professionals aged 40–75 years from across the United States in 1986.

The scientists established modifiable risk scores (MRS) for every single participant primarily based on recognized modifiable chance things for IBD to estimate the proportion of IBD instances that could have been averted. Danger elements included fat (physique mass index, BMI) cigarette smoking use of non-steroidal anti-inflammatory medicines actual physical exercise and daily intake of fruit, fiber, veggies, polyunsaturated fatty acids, and purple meat.

The researchers then approximated the proportion of avoidable situations if an overall healthier way of life were adopted and maintained. A healthier way of living comprised: BMI involving 18.5 and 25, never cigarette smoking, at minimum 7.5 weekly Satisfied hours (METS categorical the volume of energy (calories) expended for each moment of physical action) and at the very least 8 daily servings of fruit and vegetables, significantly less than 50 percent a each day serving of crimson meat, at the very least 25 g of fiber per working day, at least 2 weekly servings of fish at the very least 50 percent a everyday serving of nuts/seeds, and a optimum of 1 alcoholic consume/working day for women of all ages or 2 for males.

Based mostly on the MRS scores, the scientists approximated that a small MRS could have prevented 43{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} and 44.5{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f}, respectively, of Crohn’s disease and UC scenarios, the BMJ explained.

Equally, maintaining a nutritious life style could have prevented 61{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} of Crohn’s illness circumstances and 42{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} of UC scenarios.

“Lifestyle modification might be an desirable focus on for foreseeable future avoidance techniques in IBD,” the authors wrote. “This might be of certain relevance to superior-hazard groups, these kinds of as initially-degree relatives of IBD clients, who have an believed 2{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f}–17{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} chance of producing the disease over their life span.”

A important assumption of the conclusions is that the marriage between life-style elements and IBD enhancement is causal, the scientists additional. “Though this has but to be established, quite a few strains of proof support the significant part of environmental and life style aspects in the development of IBD.”

References

1. Lopes EW, Chan SSM, Music M, et al. Life style things for the prevention of inflammatory bowel disorder. Gut. 2022. doi:10.1136/gutjnl-2022-328174

2. Retaining healthy life style may well protect against up to 60{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} of inflammatory bowel sickness situations. News launch. BMJ. December 6, 2022. Accessed December 16, 2022. https://www.eurekalert.org/news-releases/973192

To prevent medical debt, the U.S. could learn from Germany’s health care system : Shots

To prevent medical debt, the U.S. could learn from Germany’s health care system : Shots

Dr. Eckart Rolshoven examines a patient at his clinic in Püttlingen, a small town in Germany’s Saarland region. Although Germany has a largely private health care system, patients pay nothing out-of-pocket when they come to see him.

Pasquale D’Angiolillo for KHN


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Pasquale D’Angiolillo for KHN


Dr. Eckart Rolshoven examines a patient at his clinic in Püttlingen, a small town in Germany’s Saarland region. Although Germany has a largely private health care system, patients pay nothing out-of-pocket when they come to see him.

Pasquale D’Angiolillo for KHN

PÜTTLINGEN, Germany — Almost every day, Dr. Eckart Rolshoven sees the long shadow of coal mining in his clinic near the big brownstone church that dominates this small town in Germany’s Saarland.

The region’s last-operating coal shaft, just a few miles away, closed a decade ago, ending centuries of mining in the Saarland, a mostly rural state tucked between the Rhine River and the French border. But the mines left a difficult legacy, as they have in coal regions in the United States, including West Virginia.

Many of Rolshoven’s patients battle lung diseases and chronic pain from years of work underground. “We had an industry with a lot of illnesses,” said Rolshoven, a genial primary care physician who at 71 is nearing the end of a long career.

The Saarland’s residents are sicker than elsewhere in Germany. And like West Virginia, the region faces economic hurdles. For decades, German politicians, business leaders and unions have labored to adjust to the mining industry’s slow demise.

But this is a healthier place than West Virginia in many respects. The region’s residents are less likely to die prematurely, data shows. And on average, they live four years longer than West Virginians.

There is another important difference between this former coal territory and its Appalachian counterpart: West Virginia’s economic struggles have been compounded by medical debt, a burden that affects about 100 million people in the U.S. — in no state more than West Virginia.

In the Saarland, medical debt is practically nonexistent. It’s so rare in Germany that the federal government’s statistical office doesn’t even track it.

The reason isn’t government health care. Germany, like the U.S., has a largely private health care system that relies on private doctors and private insurers. Like Americans, many Germans enroll in a health plan through work, splitting the cost with their employer.

But Germany has long done something the U.S. does not: It strictly limits how much patients have to pay out of their own pockets for a trip to the doctor, the hospital or the pharmacy.

Rolshoven’s patients pay nothing when they see him. That not only bolsters their health, he said. It helps maintain what Rolshoven called social peace. “It’s really important not to have to worry about these problems,” he said.

German health officials, business leaders and economists say the access to affordable health care has also helped the Saarland get back on its feet economically, bolstered by the assurance that workers could get to the doctor.

“Without this, the Saarland would be dead,” said Beatrice Zeiger, managing director of the Arbeitskammer des Saarlandes, a regional labor group. “It’s unthinkable.”

While health costs rise in the U.S., Germany contains them

In West Virginia, whose wooded valleys and decaying industrial plants could be mistaken for the Saarland’s, access to health coverage has been important as the state weathered the decline of its mines.

A decade ago, state leaders moved to expand the Medicaid insurance program through the Affordable Care Act. And as of last year, just 6{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} of state residents were uninsured, less than half the rate before the 2010 law.

But growing numbers of West Virginians without government insurance are in private health plans with deductibles that require they pay thousands of dollars out of their own pockets before coverage kicks in.

The typical individual health plan an American gets through work now comes with a more than $1,500 deductible, a particularly big sum in a state like West Virginia where residents often earn less than residents of other states.

That, in turn, is driving medical debt. A quarter of West Virginians with a credit report have medical bills in collections, almost twice the national rate, according to data compiled by the nonprofit Urban Institute. In several counties in the state, the rate is about a third.

And those figures likely understate the problem. Many more people put medical bills on their credit cards, borrow from family or enroll in installment plans with a hospital or other providers to pay off their bills.

“It’s a huge problem here,” said Jessica Ice, executive director of West Virginians for Affordable Health Care. “Folks with medical debt aren’t able to apply for loans to start a business or buy a starter home for their family. It’s really preventing people from climbing up the economic ladder.”

In German health plans, known as sickness funds, there aren’t typically deductibles.

Physician visits are almost always free for patients. Copays for most prescription drugs are capped at 10 euros or less, about $10. And people admitted to the hospital pay only 10 euros a day.

“Access to medical care with minimal costs for patients has been essential,” said Armin Beck, regional director of the Knappschaft Bahn See, of KBS, a health insurance plan whose roots stretch back to the 13th century, when miners set up a mutual aid society to protect one another in case of injuries or accidents. “This has been a foundation of our community,” Beck said.

‘So glad we don’t have to worry’

Along the Saar River in Germany, rusting steelworks and shuttered coal-fired power plants bear testament to the region’s economic struggles. Many towns like Püttlingen carry on in the shadow of hulking mounds of debris — Berghalde, as they are called — the detritus left behind as coal was separated from the rocky earth hauled up from underground.

The now-shuttered Bergwerk Saar coal mine in Germany’s Saarland closed in 2012, ending centuries of mining in the region. Coal from the Saarland helped fuel Germany’s industrialization and once employed tens of thousands of workers.

Pasquale D’Angiolillo for KHN


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Pasquale D’Angiolillo for KHN


The now-shuttered Bergwerk Saar coal mine in Germany’s Saarland closed in 2012, ending centuries of mining in the region. Coal from the Saarland helped fuel Germany’s industrialization and once employed tens of thousands of workers.

Pasquale D’Angiolillo for KHN

Today, new challenges confront the region. Ford, which has operated a car factory here for decades, plans to shutter the plant in a few years and move production to Spain.

But at Rolshoven’s clinic — a small set of offices tucked into a residential neighborhood — few patients can conceive of the burdens that medical bills put on Americans.

Andrea Fecht, 63, who has diabetes and came to see Rolshoven because recent tests revealed a concerning rise in her blood sugar, estimated she pays 120 euros a year, or about $125, to fill all six of her prescriptions, including her daily insulin.

In the U.S., the average price for insulin alone is nine times that in Germany, according to a recent report from Rand Corp., a research group.

Andreas Mang, a former miner who left the industry 20 years ago after a series of accidents, would likely pay even more out-of-pocket for his family’s drugs. Mang’s wife recently underwent a course of chemotherapy that would cost thousands of dollars if not for Germany’s limits on medical bills, Rolshoven said.

“I can’t imagine what it would be like not to have this support,” Mang said.

Christine Wagner said she’s had a glimpse of what Americans face. Wagner’s 18-year-old son, Jonas, has Down syndrome and has required more than 20 surgeries.

In global Facebook groups with other parents who have children with disabilities, Wagner said she’s amazed to see how much fundraising American parents do to pay family medical bills. “I’m so glad we don’t have to worry about that,” she said. “We have enough to do looking after Jonas.”

Countries where health care is actually affordable

International surveys underscore the difference Wagner observed between her experiences and those of American families.

In one recent study of health care in 11 high-income countries, the nonprofit Commonwealth Fund found that 44{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} of Americans had out-of-pocket medical expenses that topped $1,000 in the previous year. Just 16{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} of Germans reported paying that much. The rates were even lower in France, at 10{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f}, and Great Britain, where only 7{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} reported similar medical expenses.

U.S. patients were also more than twice as likely as patients in any of the 10 other countries studied to say they had serious problems paying medical bills.

“Many Americans may not understand how affordable health care is for patients in other countries,” said Reginald D. Williams II, who oversees international research at the Commonwealth Fund. “Medical debt is a largely U.S. phenomenon. It just doesn’t happen in other countries.”

Most wealthy countries in Western Europe, East Asia and elsewhere limit patients’ out-of-pocket costs.

In the Netherlands, where patients enroll in private health plans as they do in Germany, insurers typically cover all medical expenses after patients pay a standard deductible of 385 euros, or about $400. Physician visits are fully covered.

In Great Britain, where medical care that is “free at the point of service” has been a foundation of that country’s government-run National Health Service for almost 75 years, there are rarely any doctor or hospital bills.

When the government asked Britons who’d gone into debt about the causes, just 2{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} cited paying for medical treatment. A similar share attributed their debt to gambling or another habit.

In the U.S., 41{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} of adults currently have debt from medical or dental bills, according to a KFF poll.

How Germany regulates hospital, doctor and drug prices

Germany’s strict limits on medical bills have periodically stoked concerns about patients overusing the health system.

But when health plans tried implementing a copay of 10 euros for physician visits, it was quickly rolled back amid criticism from patients and frustration among doctors, who didn’t like chasing after their patients for bills.

Germany’s limits on how much patients pay out-of-pocket at the doctor’s office have been critical to ensuring people get needed care, especially in a mining region where many battle lung diseases and chronic pain, says Dr. Eckart Rolshoven. “We had an industry with a lot of illnesses,” he says.

Pasquale D’Angiolillo for KHN


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Pasquale D’Angiolillo for KHN


Germany’s limits on how much patients pay out-of-pocket at the doctor’s office have been critical to ensuring people get needed care, especially in a mining region where many battle lung diseases and chronic pain, says Dr. Eckart Rolshoven. “We had an industry with a lot of illnesses,” he says.

Pasquale D’Angiolillo for KHN

At the hospital in Püttlingen, which is operated by the Knappschaft, Dr. Marion Bolte said asking patients to pay more isn’t worth the risk, even if it might bring in more money.

“It’s better to have 20 unnecessary visits than to have one patient get harmed because they didn’t come to the hospital because they were worried about how much it would cost,” said Bolte, the chief medical officer. “We don’t want patients to worry about money. We want them to worry about getting better.”

Nationally, German patients are less likely than Americans to die from conditions that can be treated with good access to medical care, such as heart attacks, diabetes, pneumonia and some cancers, according to regional data compiled by the Paris-based Organization for Economic Cooperation and Development.

Germans are also less likely than Americans to say they had to wait to see a doctor, surveys show.

Lower-cost health care that protects workers from going into debt has meant fewer concerns for the Saarland’s policymakers, as well. “All that our predecessors had to worry about was creating jobs,” said Oliver Groll, a senior official at IHK Saarland, the regional chamber of commerce. “Health care took care of itself.”

As mining jobs disappeared, the Saarland shifted toward other industries, such as auto manufacturing, which has been a major employer since Ford opened its factory in 1970, sparking the development of a robust auto parts sector. The chamber and other business leaders are now working to lure technology and pharmaceutical jobs to the region.

For Mang, the former miner whose wife had cancer, knowing that medical bills wouldn’t drive him into debt helped give him the peace of mind to switch careers. “I never had to think about how much health care would cost me,” said Mang, who is now a nurse.

Maintaining this system has required that Germany do something else that U.S. policymakers have historically eschewed. Germany, like most wealthy nations, regulates the prices that hospitals, doctors and drugmakers can charge. This regulation occurs through a highly structured system in which insurers negotiate collectively with physician and hospital groups to set prices.

American hospitals and other medical providers for decades have fiercely resisted limits on their prices, spending millions to fight government regulation.

Price regulation can put more financial pressure on providers, who, unlike their American counterparts, can’t just demand higher prices from insurers to bolster their bottom lines.

Mario Schüller, the hospital administrator who runs the Knappschaft hospital in Püttlingen, said hospitals must instead compete to attract patients with better care and better customer service. Those that can’t compete may close, he said.

But Schüller said he wouldn’t want to charge patients more, even if he could.

“If I had to bill patients and then try to collect from them, I’d have to pay for all that,” he said. “We’d need new staff, who would have to get paid. And if we used collections companies, they’d have to be paid, too. It becomes a devil’s bargain.”

KHN (Kaiser Health News) is a national newsroom that produces in-depth journalism about health issues. Together with Policy Analysis and Polling, KHN is one of the three major operating programs at KFF (Kaiser Family Foundation). KFF is an endowed nonprofit organization providing information on health issues to the nation.

Why a Healthy Lifestyle Is Not Enough to Prevent Dementia

Summary: The alternatives for a healthful way of life are unequally dispersed and being socially deprived with a larger danger of producing Alzheimer’s illness.

Supply: University of Leipzig

Dementia is on the rise in Germany. In the absence of therapy possibilities, the focus is shifting to protecting against dementia. In particular, a healthful lifestyle is regarded as beneficial for brain health and fitness.

A examine by the College of Medication now shows that possibilities for a healthy lifestyle are unequally dispersed: being socially disadvantaged is associated with a greater risk of dementia. The present findings have been published in the Journal of Alzheimers Sickness.

As the population ages, dementia is on the rise. Currently, about 1.8 million individuals in Germany suffer from dementia. Inhabitants studies forecast an raise to about 3 million by 2050. Global investigation demonstrates terrific opportunity for dementia avoidance primarily based on modifiable health and way of life elements, these types of as hypertension, being overweight, physical and mental activity, and eating plan. In other text: a wholesome life-style is superior for mind health.

“But the alternatives are unequally distributed,” states Dr. Susanne Röhr, head of the recent research and a researcher at the Institute of Social Drugs, Occupational Medication and Community Well being (ISAP) at Leipzig College. “Socially disadvantaged individuals, these kinds of as individuals on very low incomes, have a tendency to have a better risk of dementia.”

The scientists used facts from much more than 6,200 participants in the Existence Adult review at the Leipzig Study Middle for Civilization Ailments. The proportion of females and adult males was the similar. The topics had been concerning 40 and 79 many years aged and ended up not affected by dementia.

The significant knowledge foundation of the populace-dependent cohort examine permits the Leipzig researchers to map a advanced life-style index with twelve modifiable hazard factors for dementia.

These contain hypertension, actual physical activity, smoking, obesity, and nutritional behavior. Subsequently, the impact of the index on the partnership involving socio-economic factors such as training, occupational position, and family cash flow, and psychological general performance and benefits of neuropsychological checks, is examined.

Why a Healthy Lifestyle Is Not Enough to Prevent Dementia
The effects of the present-day review demonstrate that dissimilarities in psychological efficiency thanks to social inequalities are associated to modifiable wellbeing and life style elements for dementia. Graphic is in the community domain

The final results of the current examine present that variances in psychological performance because of to social inequalities are linked to modifiable wellness and life style aspects for dementia.

“This implies that way of life interventions could mitigate social inequalities in cognitive general performance,” adds Professor Steffi Riedel-Heller, director at ISAP.

According to the researchers, on the other hand, wellness and lifestyle factors only make clear dissimilarities in mental efficiency thanks to socio-economic variables to a smaller extent. The examine findings hence also recommend that the greater emphasis may possibly be on the social circumstances them selves.

“Political steps aimed at reducing social inequalities could thus contribute noticeably to minimizing the chance of dementia,” states Dr. Röhr.

About this way of life and dementia research news

Writer: Press Office environment
Source: University of Leipzig
Speak to: Push Business – University of Leipzig
Image: The impression is in the public domain

See also

This shows a sad looking man

Initial Investigation: Closed accessibility.
“Socioeconomic Inequalities in Cognitive Functioning Only to a Tiny Extent Attributable to Modifiable Overall health and Way of living Variables in Men and women Devoid of Dementia” by Susanne Röhr et al. Journal of Alzheimer’s Condition


Abstract

Socioeconomic Inequalities in Cognitive Functioning Only to a Modest Extent Attributable to Modifiable Well being and Life style Elements in People Devoid of Dementia

Qualifications: There are socioeconomic inequalities in dementia possibility. Underlying pathways are not properly acknowledged. Aim:To investigate whether modifiable wellness and way of life aspects for brain health mediate the association of socioeconomic status (SES) and cognitive performing in a inhabitants without dementia.

Approaches: The “LIfestyle for Mind health” (LIBRA) rating was computed for 6,203 baseline individuals of the Lifetime-Grownup-Research. LIBRA predicts dementia in midlife and early late daily life, primarily based on 12 modifiable components. Associations of SES (schooling, internet equivalence profits, and occupational standing) and LIBRA with cognitive working (composite rating) had been investigated applying modified linear regression designs. Bootstrapped structural equation modelling (SEM) was used to investigate no matter whether LIBRA mediated the association of SES and cognitive working.

Results: Participants have been M = 57.4 (SD = 10.6, selection: 40-79) yrs old 50.3{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} have been feminine. Both equally, SES (Wald: F(2)=52.5, p < 0.001) and LIBRA (Wald: F(1)=5.9, p < 0.05) were independently associated with cognitive functioning there was no interaction (Wald: F(2)=2.9, p = 0.060). Lower SES and higher LIBRA scores indicated lower cognitive functioning. LIBRA partially mediated the association of SES and cognitive functioning (IE: =0.02, 95{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} CI [0.02, 0.03], p < 0.001). The proportion mediated was 12.7{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f}.

Conclusion: Differences in cognitive functioning due to SES can be partially attributed to differences in modifiable health and lifestyle factors but to a small extent. This suggests that lifestyle interventions could attenuate socioeconomic inequalities in cognitive functioning. However, directly intervening on the social determinants of health may yield greater benefits for dementia risk reduction.

EU Health Commissioner proposes MDR delay to prevent medical device shortages

Dive Brief:

  • The European Union Health Commissioner has proposed delaying enforcement of the Medical Devices Regulation (MDR) by three to four years to prevent product shortages.
  • EU Health Commissioner Stella Kyriakides seeks to pair the delay with “additional measures to address the structural problems” of MDR, including the need for targeted solutions to the problems facing rare disease devices.
  • One critic of the extension called it a “sticking plaster solution,” using the British term for a Band-Aid.

Dive Insight:

A steady stream of warnings about the impact of MDR on medical device supply again has driven the EU to act. Officials changed the original timeline in response to the COVID-19 pandemic and allowed devices with valid certificates under the old directives to stay on the market until 2024. However, as the deadline has approached, worries that the EU lacks the capacity to process the backlog have intensified. 

Six new notified bodies have received MDR designation since June, creating a pool of 36 organizations that need to process around 23,000 certificates by May 2024 if all current devices are to stay on the market. The equation has led Kyriakides to accept that a delay is necessary.

“The transition to the new rules has been slower than we anticipated. The pandemic, shortages of raw materials caused by Russian war against Ukraine and low notified body capacity has put a strain on market readiness,” Kyriakides said. “We are facing a risk of shortages of life-saving medical devices for patients. This is a risk we cannot take.”

Noting factors that have “put a strain on market readiness,” Kyriakides outlined plans to delay the deadline for MDR certification to 2027 for high-risk devices and 2028 for medium and low-risk devices. 

As well as extending the validity of directive certificates, Kyriakides is proposing to remove the “sell-off” date that would have required some marketed medical devices to be discarded in May 2025. The plan is to have the amendment ready for review by EU politicians at the start of next year.

If passed into law early in 2023, the amendment will give the EU, manufacturers and notified bodies four to five years, depending on the risk classification of a device, to fix the problems that have forced officials to twice delay MDR. 

The decision was derided by attorney Alison Dennis, a London-based international co-head of life sciences and healthcare at law firm Taylor Wessing, as “a sticking-plaster solution.” In an emailed comment, she said it imposes “an administrative burden for both companies and competent authorities to have to make these applications,” adding that “their time would be better spent on getting medical devices certified under the [existing] Regulations.” 

Dennis said it would be preferable for the new rules to provide for an automatic extension of existing certification. “Manufacturers are likely to have to ask and potentially ask repeatedly for extensions,” she said.

Kyriakides, the EU commissioner, also spoke about the Commission’s efforts to support solutions for rare diseases. 

“We should develop together solutions on orphan devices, to ensure patients with rare diseases continue to have access to those devices,” Kyriakides said. “We must also shape a regulatory environment that fosters innovation and ensures that notified bodies are enabled to focus on the key task at hand, patient safety and less bureaucracy.” 

Kyriakides’ focus on orphan devices is in line with the concerns raised by the Biomedical Alliance in Europe, which recently called for a special framework for orphan medical devices. The EU Health Commissioner also outlined plans for a pilot project that will “offer scientific advice from the expert panels on medical devices” to manufacturers of orphan and breakthrough devices and for more support for small and medium-size enterprises.

Can a Healthy Lifestyle Prevent IBD?

Adopting and maintaining a healthy lifestyle may prevent inflammatory bowel disease (IBD), according to findings from an analysis of three prospective U.S. cohort studies, which were validated in three external European cohorts.

In the primary analysis, maintaining low modifiable risk scores — based on risk factors including body mass index, smoking status, use of non-steroidal anti-inflammatory drugs, physical activity, and daily consumption of fruit, vegetables, fiber, polyunsaturated fatty acids, and red meat — could have prevented 42.9{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} of Crohn’s disease cases and 44.4{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} of ulcerative colitis cases, reported Hamed Khalili, MD, MPH, of Massachusetts General Hospital in Boston, and colleagues.

Moreover, adherence to a healthy lifestyle could have prevented 61.1{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} of Crohn’s disease cases and 42.2{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} of ulcerative colitis cases, they noted in Gut.

“We were surprised by the proportion of cases that could have been prevented through lifestyle modifications,” Khalili told MedPage Today. “One reason for this finding may be that our population was older and therefore most of our cases of IBD happened in older adults.”

“We know that lifestyle and environmental factors play a bigger role in the development of IBD in this population as compared to those who are diagnosed with disease earlier in life,” he added.

These findings from the Nurses’ Health Study (NHS), the NHS II, and the Health Professionals Follow-Up Study (HPFS) were largely validated in three external European cohorts — the Swedish Mammography Cohort, Cohort of Swedish Men, and the European Prospective Investigation into Cancer and Nutrition.

Looking at cases of Crohn’s disease among the European validation cohorts, adhering to low-risk factors could have prevented 44{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} to 51{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} of cases, while adhering to a healthy lifestyle could have prevented 49{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} to 60{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} cases. For ulcerative colitis, adherence to low-risk factors could have prevented 21{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} to 28{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} of cases, while healthy lifestyle adherence could have prevented 47{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} to 56{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} of cases.

For every 1-point increase in modifiable risk score, a higher risk of Crohn’s disease (P for trend<0.0001) and ulcerative colitis (P for trend=0.008) was observed, and was similar for men and women.

IBD affects about 3.1 million people in the U.S. and 1.3 million in Europe, with incidence rising globally, especially among newly industrialized countries, Khalili’s group said. IBD is associated with an annual healthcare cost of $23,000 per patient in the U.S., and there are no current strategies to prevent the development of IBD. While one approach to preventing many chronic diseases is modification of lifestyle and dietary factors, the success of adhering to such changes remains unclear.

For this study, Khalili and colleagues examined data on 72,290 participants from the NHS, 93,909 from the NHS II, and 41,871 from the HPFS. The NHS enrolled female nurses ages 30 to 55 across 11 states in 1976. NHS II assessed a slightly younger cohort of female nurses (ages 25 to 42) from 15 states starting in 1989, while the HPFS enrolled male physicians ages 40 to 75 across all states in 1986.

In order to externally validate their findings, the researchers assessed data on 40,810 participants in the Cohort of Swedish Men, 404,144 from the European Prospective Investigation into Cancer and Nutrition, and 37,275 from the Swedish Mammography Cohort.

Using participant baseline and biennial questionnaires that assessed lifestyle factors, anthropomorphic data, and medical history, Khalili and colleagues developed modifiable risk scores ranging from 0 to 6 for Crohn’s disease and ulcerative colitis, with higher scores indicating more risk factors. Healthy lifestyle scores ranging from 0 to 9 were also developed, based on recommendations from the American Heart Association and other organizations, with higher scores indicating a healthier lifestyle.

A healthy lifestyle included never smoking, a BMI between 18.5 and 25, and engaging in physical activity of at least 7.5 metabolic equivalent of task-hours per week, in addition to consuming less than half a serving of red meat per day, at least eight daily servings of fruit/vegetables, at least half a serving of nuts or seeds per day, at least two servings of fish per week, at least 25 g of daily fiber, and a maximum of one daily alcoholic beverage for women and two for men.

Across 5,117,021 person-years of follow-up, 346 cases of Crohn’s disease and 456 cases of ulcerative colitis were reported.

On falsification analysis, adherence to low-risk factors for Crohn’s disease could have also prevented 32.3{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} of cases of rheumatoid arthritis, 13.3{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} of cases of colorectal cancer, and 14{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} of cases of cardiovascular disease, though this was not the case for ulcerative colitis.

“This is largely due to differences in strength of associations and prevalence of risk factors, and presence of other modifiable risk factors such as alcohol and medications or supplements which are strongly associated with these other conditions,” Khalili and colleagues suggested.

They acknowledged that younger-onset IBD was under-represented in their study, since the mean age of the cohort (about 45) was higher than the usual age at onset of IBD. In addition, data on other modifiable risk factors such as stress were not explored, and high-risk individuals were not assessed.

  • Can a Healthy Lifestyle Prevent IBD?

    Zaina Hamza is a staff writer for MedPage Today, covering Gastroenterology and Infectious disease. She is based in Chicago.

Disclosures

This study was primarily supported by the National Institutes of Health.

Khalili reported support from the American College of Gastroenterology Senior Research Award and the Beker Foundation, as well as consulting fees from AbbVie and Takeda, and grant funding from Pfizer and Takeda.

Co-authors also reported multiple relationships with industry.