Media Advisory

Tuesday, February 14, 2023


In a mouse research, researchers funded by the Countrywide Institutes of Health and fitness have determined a opportunity non-hormonal contraceptive that guys could get soon right before sexual activity and have fertility restored the up coming working day. Researchers gave male mice a compound that briefly disables soluble adenylyl cyclase, the enzyme vital for activating a sperm cell’s potential to swim and mature so that it can journey by way of the feminine reproductive tract and fertilize an egg.

In many checks, the researchers confirmed that the compound TDI-11861 rendered mouse sperm cells motionless and prevented them from maturing. The compounds did not interfere with the animals’ sexual performing. Even though male mice mated with women, no pregnancies ended up observed. Sperm recovered from feminine mice remained incapacitated. The authors did not observe any side results in the male or female mice. The compound wore off three several hours later on, and males recovered their fertility.

The examine was done by Melanie Balbach, Ph.D., a postdoctoral fellow in the laboratories of coauthors Jochen Buck, Ph.D., and Lonnie Levin, Ph.D., at Weill Cornell Healthcare School, New York Town, and colleagues. It appears in Character Communications. Funding was presented by NIH’s Eunice Kennedy Shriver Nationwide Institute of Baby Health and fitness and Human Progress, Countrywide Institute on Getting old, and Nationwide Cancer Institute.

The researchers say their function provides evidence of concept that soluble adenylyl cyclase inhibitors have the probable to deliver a safe, on-need, non-hormonal and reversible oral contraceptive for guys.


Christopher C. Lindsey, Ph.D., a program official in the NICHD Contraception Study Branch, is accessible for comment.


Balbach, M. Exploration Letter: On-demand male contraception by using acute inhibition of soluble adenylyl cyclase. Mother nature Communications.2022.

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