What Older Americans Need to Know About Taking Paxlovid

A new coronavirus variant is circulating, the most transmissible one yet. Hospitalizations of infected sufferers are climbing. And older adults characterize nearly 90{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} of U.S. fatalities from covid-19 in recent months, the major portion considering that the begin of the pandemic.

What does that necessarily mean for people today 65 and older catching covid for the 1st time or people dealing with a repeat an infection?

The concept from infectious disease professionals and geriatricians is very clear: Find cure with antiviral treatment, which stays effective towards new covid variants.

The remedy of 1st selection, professionals explained, is Paxlovid, an antiviral cure for people with moderate to moderate covid at superior danger of getting seriously ill from the virus. All older people 65 and up slide in that class. If folks cannot tolerate the medicine — probable troubles with other medications have to have to be meticulously evaluated by a clinical service provider — two possibilities are out there.

“There’s tons of evidence that Paxlovid can decrease the risk of catastrophic occasions that can adhere to an infection with covid in older men and women,” reported Dr. Harlan Krumholz, a professor of medicine at Yale College.

In the meantime, acquire a program for what you will do if you get covid. Exactly where will you look for treatment? What if you simply cannot get in rapidly to see your medical professional, a common trouble? You require to act rapid since Paxlovid need to be commenced no afterwards than five times right after the onset of signs or symptoms. Will you have to have to regulate your medicine program to guard against possibly perilous drug interactions?

“The time to be figuring all this out is ahead of you get covid,” said Dr. Allison Weinmann, an infectious-illness pro at Henry Ford Clinic in Detroit.

Becoming organized proved necessary when I caught covid in mid-December and went to urgent treatment for a prescription. Mainly because I’m 67, with blood most cancers and autoimmune illness, I’m at elevated hazard of receiving seriously ill from the virus. But I just take a blood thinner that can have life-threatening interactions with Paxlovid.

Thankfully, the urgent care center could see my electronic healthcare report, and a physician’s be aware there reported it was safe for me to end the blood thinner and get the treatment method. (I’d consulted with my oncologist in advance.) So, I walked away with a Paxlovid prescription, and within a working day my headaches and chills had disappeared.

Just before obtaining covid, I’d study an essential research of almost 45,000 people 50 and more mature taken care of for covid concerning January and July 2022 at Mass Basic Brigham, a massive Massachusetts wellbeing program. 20-8 {bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} of the patients had been prescribed Paxlovid, which experienced been given an unexpected emergency use authorization for moderate to moderate covid from the Fda in December 2021 72{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} had been not. All were outpatients.

In contrast to in other studies, most of the patients in this one particular experienced been vaccinated. Nonetheless, Paxlovid conferred a noteworthy gain: People who took it ended up 44{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} much less likely to be hospitalized with serious covid-relevant illnesses or die. Amid people who’d gotten much less than a few vaccine doses, these hazards were reduced by 81{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f}.

A couple of months earlier, a research out of Israel had confirmed the efficacy of Paxlovid — the brand name name for a blend of nirmatrelvir and ritonavir — in seniors contaminated with covid’s omicron strain, which arose in late 2021. (The primary examine developing Paxlovid’s performance experienced been carried out though the delta strain was commonplace and provided only unvaccinated people.) In individuals 65 and more mature, most of whom experienced been vaccinated or formerly experienced covid, hospitalizations have been lowered by 73{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} and fatalities by 79{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f}.

Continue to, several aspects have obstructed Paxlovid’s use amid older grown ups, which include doctors’ considerations about drug interactions and patients’ issues about probable “rebound” bacterial infections and facet outcomes.

Dr. Christina Mangurian, vice dean for school and academic affairs at the College of California-San Francisco School of Medicine, encountered several of these issues when both equally her mom and dad caught covid in July, an episode she chronicled in a latest JAMA write-up.

Initial, her father, 84, was explained to in a virtual health care appointment by a medical professional he didn’t know that he couldn’t consider Paxlovid for the reason that he’s on a blood thinner — a determination afterwards reversed by his principal care medical professional. Then, her mom, 78, was informed, in a separate digital appointment, to get an antibiotic, steroids, and over-the-counter medicines rather of Paxlovid. The moment yet again, her most important treatment medical doctor intervened and presented a prescription.

In equally circumstances, Mangurian stated, the medical doctors her moms and dads initial saw appeared to misunderstand who ought to get Paxlovid, and underneath what situations. “This details to a big deficit in phrases of how info about this remedy is getting disseminated to entrance-line clinical providers,” she informed me in a cell phone dialogue.

Michael Osterholm, director of the Center for Infectious Disorder Investigate and Policy at the College of Minnesota, agrees. “Every working day, I listen to from persons who are misinformed by their medical professionals or contact-in nurse strains. Usually, they are remaining informed you just can’t get Paxlovid right up until you’re very seriously ill — which is just the opposite of what’s encouraged. Why are we not undertaking extra to teach the healthcare group?”

The possible for drug interactions with Paxlovid is a important concern, specially in more mature patients with a number of clinical ailments. A lot more than 120 medicines have been flagged for interactions, and each and every case needs to be evaluated, having into account an individual’s problems, as effectively as kidney and liver perform.

The great news, gurus say, is that most potential interactions can be managed, either by quickly halting a medicine though getting Paxlovid or minimizing the dose.

“It can take a small added function, but there are methods and techniques in location that can support practitioners figure out what they should really do,” stated Brian Isetts, a professor at the College of Minnesota College or university of Pharmacy.

In nursing households, clients and people really should inquire to talk to expert pharmacists if they’re explained to antiviral therapy is not advisable, Isetts advised.

About 10{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} of patients cannot get Paxlovid due to the fact of probable drug interactions, according to Dr. Scott Dryden-Peterson, professional medical director of covid outpatient therapy for Mass Typical Brigham. For them, Veklury (remdesivir), an antiviral infusion remedy shipped on a few consecutive days, is a very good option, though often difficult to arrange. Also, Lagevrio (molnupiravir), an additional antiviral tablet, can assistance shorten the period of symptoms.

Lots of older adults concern that following taking Paxlovid they’ll get a rebound infection — a unexpected resurgence of symptoms following the virus appears to be to have run its class. But in the wide bulk of circumstances “rebound is incredibly moderate and signs or symptoms — commonly runny nose, nasal congestion, and sore throat — go absent in a few times,” reported Dr. Rajesh Gandhi, an infectious-sickness health practitioner and professor of drugs at Harvard Health-related Faculty.

Gandhi and other physicians I spoke with mentioned the chance of not dealing with covid in older older people is significantly greater than the chance of rebound illness.

Facet consequences from Paxlovid include things like a metallic style in the mouth, diarrhea, nausea, and muscle mass aches, amongst other individuals, but critical troubles are unusual. “Consistently, people are tolerating the drug truly properly,” claimed Dr. Caroline Harada, associate professor of geriatrics at the College of Alabama-Birmingham Heersink School of Medication, “and experience greater quite swiftly.”

We’re eager to listen to from visitors about thoughts you’d like answered, problems you have been obtaining with your care, and information you will need in dealing with the overall health care system. Visit khn.org/columnists to post your requests or strategies.

KHN (Kaiser Health Information) is a nationwide newsroom that generates in-depth journalism about wellbeing challenges. Jointly with Plan Evaluation and Polling, KHN is one particular of the a few main operating applications at KFF (Kaiser Family Basis). KFF is an endowed nonprofit corporation furnishing information and facts on overall health challenges to the nation.

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NIH grant helps KU provide obesity and metabolism research training for pre-doctoral graduate students

The College of Kansas Medical Middle has been awarded a prestigious grant by the National Institutes of Wellbeing to deliver training centered on being overweight and fat burning capacity for pre-doctoral graduate learners. Recognised as a T32 education grant, the 5-yr, $1.3 million award is a different aspect of KU Professional medical Center’s rising exploration endeavours to fight obesity and obesity-linked illnesses and problems.

Additional than 40{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} of American grownups and 20{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} of children and adolescents have weight problems, in accordance to the Centers for Disorder Handle and Prevention. All those studies are on the rise nationally and in Kansas. In 2019, Kansas grew to become a single of the 19 states with an being overweight rate of at the very least 35{bf0515afdcaddba073662ceb89fbb62b6b1bf123143c0e06b788e1946e8c353f} for grown ups.

Weight problems substantially improves a person’s chance of building cardiovascular conditions, Form 2 diabetic issues, kidney condition, fatty liver, orthopedic problems and a assortment of cancers. It also can induce debilitating suffering and contributes to psychological wellness challenges these kinds of as panic and despair. Around the earlier three yrs, weight problems has proved to be a considerable factor in COVID-19 patients’ prospects of dying.

Bridging the divides in research

The difficulty and the figures are obvious, but the ailment is intricate. Genetics, biology, behavior, environmental factors and social determinants all enjoy a part in what triggers a person to be overweight. However, men and women researching obesity and weight problems-relevant illnesses have a tendency to carry out their analysis in silos. This T32 grant will be applied to coach experts who bridge the divide involving investigate on weight problems and conditions prompted by weight problems, and between standard laboratory science (e.g., genetics and biology) and more scientific exploration (e.g., psychology and dietetics).

“There are people today who only concentration on obesity and men and women who aim on the pathologies linked with being overweight. And all those two camps do not normally function with each other,” mentioned John Thyfault, Ph.D., co-principal investigator on the grant and professor of mobile biology and physiology at KU Health care Centre. “A major component of our grant [application] was the concept that to efficiently handle weight problems-induced pathologies, you require to have some understanding of how weight problems develops and how it really is connected to that disorder.”

Thyfault also pointed to yet another problem: “Basic scientists performing with cell cultures and animal products you should not usually speak to the persons accomplishing the clinical exploration, and vice versa. So, one more objective is to teach the trainees about these different realms of study and how to integrate them.”

The grant is supporting 3 students this 1st yr. Two arrive from a standard-science qualifications while the 3rd is a medical researcher. The essential-science college students are supplied clinical mentors, even though the scientific researcher has been offered an extra fundamental-science mentor. In addition, the learners have an advisory committee with primary, scientific and translational science know-how. All trainees will take part in seminars and just take lessons on obesity and biostatistics.

“We anticipate that college students entering the system in potential several years will carry on to arrive from both of those standard and scientific departments,” mentioned Doug Wright, Ph.D., co-principal investigator on the grant and professor of anesthesiology at KU Health-related Middle. “For people students who are viewing people in the clinic, understanding how to investigate the molecular biology [behind the disease] will aid them enhance their ways to affected individual care.”

Invaluable for clients

Sarah Thomas is an M.D./Ph.D. student supported by the new grant who is currently focused on the Ph.D. element of her degree and teaching in a lab. She just completed taking “Intervention for the Prevention and Administration of Obesity,” a scientific class available via the Department of Dietetics and Nourishment at KU College of Wellness Professions.

“I hadn’t gained much diet instruction in advance of, and they do not shell out a good deal of time on it in medical college,” she stated. “We learned much more functional data, this sort of as the significance of ingesting breakfast and recommendations such as seeking to try to eat soup or salad right before having a food and not consuming a several hrs before bedtime. These are way of living variations. And I come to feel like that’s like a must have for most sufferers.”

Health care capitalists want to see profits, not just cool ideas : Shots

Health care capitalists want to see profits, not just cool ideas : Shots

The Westin St. Francis San Francisco on Union Square lodge hosted this year’s JPMorgan Healthcare Meeting — the very first considering the fact that the onset of the coronavirus pandemic. (Darius Tahir/KHN)

Darius Tahir/KHN


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Darius Tahir/KHN


The Westin St. Francis San Francisco on Union Square hotel hosted this year’s JPMorgan Healthcare Meeting — the initial given that the onset of the coronavirus pandemic. (Darius Tahir/KHN)

Darius Tahir/KHN

SAN FRANCISCO — Wellness care’s enterprise course returned to its San Francisco sanctuary last week for JPMorgan’s yearly wellness care confab, at the gilded Westin St. Francis lodge on Union Square. Immediately after a two-calendar year pandemic pause, the temper between the executives, bankers and startup founders in attendance experienced the aura of a reunion — as they gossiped about promotions, operate-from-property routines, who’s obtaining what investments. Dressed in their capitalist greatest — ranging from amazing-blue or pastel-purple blazers to puffy-coat chic — they thronged to huge get-togethers held in art galleries and places to eat.

But the occasion was tinged with new anxiousness: Would the massive revenue invested in wellbeing treatment owing to COVID-19 go on to movement? Would traders check with to see success — which means profits — fairly than just cool tips?

The buzzy meeting had just as many text about gains as about sufferers. The generally maskless crowd spoke English, French, Japanese — and, of study course, funds.

Other than the company and expense types, attendees routinely noticed stunning characters — like movie star physician Mehmet Oz, fresh off his Senate loss, keeping courtroom in the foyer on Jan. 10.

If the vibe in the hotel’s congested halls was upbeat — or, at least, cheery — beneath there was a frisson of stress and anxiety as all were informed that the wellbeing care business bonanza appears to be slowing down.

The convention began with a sidewalk protest of pharmaceutical business Gilead Sciences, whose prescription drugs combating HIV and hepatitis C are fabulously powerful — and fabulously high-priced. All through the pandemic, Congress for the 1st time has set up a plan to permit Medicare to negotiate U.S. drug rates, which are by considerably the optimum in the entire world. In a statement, corporation spokesperson Catherine Cantone mentioned Gilead is the largest personal funder of HIV courses in the U.S., introducing, “Gilead’s function in ending the HIV and hepatitis epidemics is to discover, produce, and ensure access to our daily life-preserving medications.”

‘A challenging year’

Then there’s the economic ecosystem, which is turning treacherous. Journalists at money publication Bloomberg identified a lack of fascinating offers. Startup executives — who beforehand found tens of millions of pounds in investments quick to arrive by — appeared obligated to demonstrate benefits in their impromptu pitches in bars and coffee outlets. Organization executives of all stripes promised they possibly at present manufactured earnings or were being about to … soon.

“I consider this is a tricky calendar year,” claimed Hemant Taneja, CEO of the enterprise money firm Common Catalyst, all through a person panel. He proposed that massive swaths of well being tech startups were being overvalued and that their shoppers will be additional interested in no matter whether they’re in fact offering handy products and services.

The new message from opportunity buyers was obvious. “The notion you could develop and not be lucrative is useless, absent,” mentioned Dr. Jon Cohen, CEO of the psychological health and fitness startup Talkspace, in an job interview.

Some tried using to celebrate the two economic and humanitarian success. BioNTech co-founder Uğur Şahin was interrupted by applause during a presentation as the developer, with Pfizer, of the mRNA vaccine recounted the shots’ part in combating the pandemic. And that was just before he touted his firm’s part in minimizing infectious ailment, saving lives, and conference international health demands for tuberculosis and malaria.

The conversation afterwards turned to the pricing of his company’s flagship vaccine — which it is really jockeying to set at extra than $100 a dose, up from an typical governing administration purchase price tag of $20.69. A hundred bucks is a truthful price tag taking into consideration the “wellbeing economics,” BioNTech’s chief tactic officer, Ryan Richardson, argued: the hospitalizations and critical results averted.

A mind-bending comment

There was some cognitive dissonance at the conference. Look at drugstore giant CVS — which is steadily growing over and above its retail roots into health coverage and main treatment. CVS Well being CEO Karen Lynch said that as section of its health business enterprise the business is searching at all the aspects that underlie being very well. “Wellness is not just about the engagement with the provider it really is about all the other variables — which include housing and nutrition,” she explained. Still left unaddressed was the sight usually greeting CVS consumers on moving into a shop: candy, chips, and other processed foods.

For critics, it was a thoughts-bending comment. “The final I read, CVS was a for-revenue corporation, not a social welfare company,” explained Marion Nestle, a researcher who is a longtime critic of the food stuff market. “It sells junk meals that make people sick and medicine to deal with those people ailments. How’s that for a nifty organization design!”

CVS spokesperson Ethan Slavin offered a quite unique eyesight, one particular in which CVS is seeking to be a leading health and wellness location. “We’re normally evolving our foodstuff and beverage assortment to deliver more healthy, on-trend solutions.” It is also supporting packages to bolster food stuff availability in underserved regions, he additional.

Some techies encountered new skepticism about “artificial intelligence.” Ginkgo Bioworks co-founder Jason Kelly mentioned through his presentation that persons at the convention listened to so significantly about synthetic intelligence all through the meetings, “they want to quit listening to it.” (Ginkgo’s AI, utilized to guidance pharmaceutical and biotech analysis, he stated, was different than the rest.)

A person surgeon, Dr. Rajesh Aggarwal, found discussions with financiers about the stealth startup he launched, which focuses on metabolic health, were centered on silver bullets. “Convey to me if I spend in this, I will 10x” the outlay, he reported, paraphrasing the bankers. Many, he reported, wished to “do some good as perfectly” for individuals.

Aggarwal felt the buyers were being wanting for simple alternatives to overall health troubles. And a person product match that invoice: a new class of drugs — GLP-1 agonists, a style of medication that aids in bodyweight decline but will possible have to be taken for extended durations. Some analysts are projecting these medicine will be really worth $50 billion. The bankers, Aggarwal felt, usually are not “pondering about health care,” they are “imagining about the bucks attached to the capsule.”

KHN (Kaiser Overall health Information) is a countrywide, editorially impartial method of the Kaiser Household Foundation.

Simple Ayurvedic remedies to keep your eyes healthy

It would not be completely wrong to say that wanting at our phones is the to start with and the very last thing we do in a working day. In addition, we maintain staring at various screens — from mobiles and laptops to even television — for the duration of the day. So, it is not stunning to know that this routine can get a toll on our eyes, major to discomfort, itching, and usually even building them watery or dry, eventually primary to strained and fatigued eyes.

That is precisely what Dr Dimple Jangda, an Ayurveda skilled, highlighted in an Instagram post, in which she reported that we place stress on our eyes with the over utilization of electronic devices and exposure to as well significantly gentle. She extra that, in accordance to Ayurveda, the eye muscular tissues are governed by the earth ingredient, the blood vessels by hearth, the eye color by air, the eye’s white region by h2o, and the tear ducts and channels by space. “Eyes are the seat of the pitta dosha,” she ongoing.

As such, to continue to keep your eyes nutritious, Dr Dimple recommended the top rated 5 remedies:

*As for every Ayurveda, it is advised to wash your eyes with cold water in the morning though keeping drinking water in the mouth. “Very incredibly hot or pretty cold drinking water ought to not be employed for washing the eyes,” warned Dr Dimple.

*To enhance eyesight, she recommended ‘Tratak’ medication. It demands seeking intensely at a ghee lamp lit with a cotton wick.

*A quick and successful way to soothe exhausted eyes is to spot goat milk-soaked cotton balls more than them.

*Dr Dimple also suggested an Ayurvedic solution for dry eyes — putting a drop of pure castor oil in the two eyes together with implementing the oil on the soles of the toes.

*Cucumber slices also enable soothe the eyes with their cooling result. Alternatively, you can also use teabags that have catechins (a chemical compound) in them.

Adding, Dr Yogini Patil, BAMS and Nutritionist at LivLong, mentioned, “Ayurveda, the ancient Indian medication method, gives many very simple solutions to manage nutritious eyes. Between all perception organs, the eye, also recognized as नेत्रम् (netram) in Sanskrit, has been supplied key relevance due to its function. The Ayurvedic remedy for eyes will take a holistic strategy to strengthen eyesight. Ayurveda aims to take care of health concerns from their root. While this may well take considerable time to show effects, the outcome is very long-lasting and comprehensively rejuvenating.”

She shared the adhering to strategies:

*A person well-known cure is to mix honey and ghee and utilize it around the eyes in advance of bedtime. It allows moisturise the eyes and lessen dryness.
*Yet another cure is to soak Triphala, a blend of three fruits, in water right away and use the drinking water as an eye clean in the morning. It aids increase eyesight and decrease redness and swelling.
*Ingesting foods abundant in vitamin A, this kind of as carrots and leafy greens, is also helpful for sustaining balanced eyes.
*Practising yoga asanas these types of as Shirshasana and Trataka can also increase eyesight and decrease strain on the eyes.

“It is constantly vital to check with with an Ayurvedic practitioner just before indulging in any new remedy routine,” the professional explained.

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Therapy by AI holds promise and challenges : Shots

Therapy by AI holds promise and challenges : Shots
Some companies and researchers think smart computers might eventually help with provider shortages in mental health, and some consumers are already turning to chatbots to build "emotional resilience."

Just a year ago, Chukurah Ali had fulfilled a dream of owning her own bakery — Coco’s Desserts in St. Louis, Mo. — which specialized in the sort of custom-made ornate wedding cakes often featured in baking show competitions. Ali, a single mom, supported her daughter and mother by baking recipes she learned from her beloved grandmother.

But last February, all that fell apart, after a car accident left Ali hobbled by injury, from head to knee. “I could barely talk, I could barely move,” she says, sobbing. “I felt like I was worthless because I could barely provide for my family.”

As darkness and depression engulfed Ali, help seemed out of reach; she couldn’t find an available therapist, nor could she get there without a car, or pay for it. She had no health insurance, after having to shut down her bakery.

So her orthopedist suggested a mental-health app called Wysa. Its chatbot-only service is free, though it also offers teletherapy services with a human for a fee ranging from $15 to $30 a week; that fee is sometimes covered by insurance. The chatbot, which Wysa co-founder Ramakant Vempati describes as a “friendly” and “empathetic” tool, asks questions like, “How are you feeling?” or “What’s bothering you?” The computer then analyzes the words and phrases in the answers to deliver supportive messages, or advice about managing chronic pain, for example, or grief — all served up from a database of responses that have been prewritten by a psychologist trained in cognitive behavioral therapy.

That is how Ali found herself on a new frontier of technology and mental health. Advances in artificial intelligence — such as Chat GPT — are increasingly being looked to as a way to help screen for, or support, people who dealing with isolation, or mild depression or anxiety. Human emotions are tracked, analyzed and responded to, using machine learning that tries to monitor a patient’s mood, or mimic a human therapist’s interactions with a patient. It’s an area garnering lots of interest, in part because of its potential to overcome the common kinds of financial and logistical barriers to care, such as those Ali faced.

Potential pitfalls and risks of chatbot therapy

There is, of course, still plenty of debate and skepticism about the capacity of machines to read or respond accurately to the whole spectrum of human emotion — and the potential pitfalls of when the approach fails. (Controversy flared up on social media recently over a canceled experiment involving chatbot-assisted therapeutic messages.)

“The hype and promise is way ahead of the research that shows its effectiveness,” says Serife Tekin, a philosophy professor and researcher in mental health ethics at the University of Texas San Antonio. Algorithms are still not at a point where they can mimic the complexities of human emotion, let alone emulate empathetic care, she says.

Tekin says there’s a risk that teenagers, for example, might attempt AI-driven therapy, find it lacking, then refuse the real thing with a human being. “My worry is they will turn away from other mental health interventions saying, ‘Oh well, I already tried this and it didn’t work,’ ” she says.

But proponents of chatbot therapy say the approach may also be the only realistic and affordable way to address a gaping worldwide need for more mental health care, at a time when there are simply not enough professionals to help all the people who could benefit.

Someone dealing with stress in a family relationship, for example, might benefit from a reminder to meditate. Or apps that encourage forms of journaling might boost a user’s confidence by pointing when out where they make progress.

Proponents call the chatbot a ‘guided self-help ally’

It’s best thought of as a “guided self-help ally,” says Athena Robinson, chief clinical officer for Woebot Health, an AI-driven chatbot service. “Woebot listens to the user’s inputs in the moment through text-based messaging to understand if they want to work on a particular problem,” Robinson says, then offers a variety of tools to choose from, based on methods scientifically proven to be effective.

Many people will not embrace opening up to a robot.

Chukurah Ali says it felt silly to her too, initially. “I’m like, ‘OK, I’m talking to a bot, it’s not gonna do nothing; I want to talk to a therapist,” Ali says, then adds, as if she still cannot believe it herself: “But that bot helped!”

At a practical level, she says, the chatbot was extremely easy and accessible. Confined to her bed, she could text it at 3 a.m.

“How are you feeling today?” the chatbot would ask.

“I’m not feeling it,” Ali says she sometimes would respond.

The chatbot would then suggest things that might soothe her, or take her mind off the pain — like deep breathing, listening to calming music, or trying a simple exercise she could do in bed. Ali says things the chatbot said reminded her of the in-person therapy she did years earlier. “It’s not a person, but, it makes you feel like it’s a person,” she says, “because it’s asking you all the right questions.”

Technology has gotten good at identifying and labeling emotions fairly accurately, based on motion and facial expressions, a person’s online activity, phrasing and vocal tone, says Rosalind Picard, director of MIT’s Affective Computing Research Group. “We know we can elicit the feeling that the AI cares for you,” she says. But, because all AI systems actually do is respond based on a series of inputs, people interacting with the systems often find that longer conversations ultimately feel empty, sterile and superficial.

While AI may not fully simulate one-on-one individual counseling, its proponents say there are plenty of other existing and future uses where it could be used to support or improve human counseling.

AI might improve mental health services in other ways

“What I’m talking about in terms of the future of AI is not just helping doctors and [health] systems to get better, but helping to do more prevention on the front end,” Picard says, by reading early signals of stress, for example, then offering suggestions to bolster a person’s resilience. Picard, for example, is looking at various ways technology might flag a patient’s worsening mood — using data collected from motion sensors on the body, activity on apps, or posts on social media.

Technology might also help improve the efficacy of treatment by notifying therapists when patients skip medications, or by keeping detailed notes about a patient’s tone or behavior during sessions.

Maybe the most controversial applications of AI in the therapy realm are the chatbots that interact directly with patients like Chukurah Ali.

What’s the risk?

Chatbots may not appeal to everyone, or could be misused or mistaken. Skeptics point to instances where computers misunderstood users, and generated potentially damaging messages.

But research also shows some people interacting with these chatbots actually prefer the machines; they feel less stigma in asking for help, knowing there’s no human at the other end.

Ali says that as odd as it might sound to some people, after nearly a year, she still relies on her chatbot.

“I think the most I talked to that bot was like 7 times a day,” she says, laughing. She says that rather than replacing her human health care providers, the chatbot has helped lift her spirits enough so she keeps those appointments. Because of the steady coaching by her chatbot, she says, she’s more likely to get up and go to a physical therapy appointment, instead of canceling it because she feels blue.

That’s precisely why Ali’s doctor, Washington University orthopedist Abby Cheng, suggested she use the app. Cheng treats physical ailments, but says almost always the mental health challenges that accompany those problems hold people back in recovery. Addressing the mental-health challenge, in turn, is complicated because patients often run into a lack of therapists, transportation, insurance, time or money, says Cheng, who is conducting her own studies based on patients’ use of the Wysa app.

“In order to address this huge mental health crisis we have in our nation — and even globally — I think digital treatments and AI can play a role in that, and at least fill some of that gap in the shortage of providers and resources that people have,” Cheng says.

Not meant for crisis intervention

But getting to such a future will require navigating thorny issues like the need for regulation, protecting patient privacy and issues of legal liability. Who bears responsibility if the technology goes wrong?

Many similar apps on the market, including those from Woebot or Pyx Health, repeatedly warn users that they are not designed to intervene in acute crisis situations. And even AI’s proponents argue computers aren’t ready, and may never be ready, to replace human therapists — especially for handling people in crisis.

“We have not reached a point where, in an affordable, scalable way, AI can understand every sort of response that a human might give, particularly those in crisis,” says Cindy Jordan, CEO of Pyx Health, which has an app designed to communicate with people who feel chronically lonely.

Jordan says Pyx’s goal is to broaden access to care — the service is now offered in 62 U.S. markets and is paid for by Medicaid and Medicare. But she also balances that against worries that the chatbot might respond to a suicidal person, ” ‘Oh, I’m sorry to hear that.’ Or worse, ‘I don’t understand you.’ ” That makes her nervous, she says, so as a backup, Pyx staffs a call center with people who call users when the system flags them as potentially in crisis.

Woebot, a text-based mental health service, warns users up front about the limitations of its service, and warnings that it should not be used for crisis intervention or management. If a user’s text indicates a severe problem, the service will refer patients to other therapeutic or emergency resources.

Cross-cultural research on effectiveness of chatbot therapy is still sparse

Athena Robinson, chief clinical officer for Woebot, says such disclosures are critical. Also, she says, “it is imperative that what’s available to the public is clinically and rigorously tested,” she says. Data using Woebot, she says, has been published in peer-reviewed scientific journals. And some of its applications, including for post-partum depression and substance use disorder, are part of ongoing clinical research studies. The company continues to test its products’ effectiveness in addressing mental health conditions for things like post-partum depression, or substance use disorder.

But in the U.S. and elsewhere, there is no clear regulatory approval process for such services before they go to market. (Last year Wysa did receive a designation that allows it to work with Food and Drug Administration on the further development of its product.)

It’s important that clinical studies — especially those that cut across different countries and ethnicities — continue to be done to hone the technology’s intelligence and its ability to read different cultures and personalities, says Aniket Bera, an associate professor of computer science at Purdue.

“Mental-health related problems are heavily individualized problems,” Bera says, yet the available data on chatbot therapy is heavily weighted toward white males. That bias, he says, makes the technology more likely to misunderstand cultural cues from people like him, who grew up in India, for example.

“I don’t know if it will ever be equal to an empathetic human,” Bera says, but “I guess that part of my life’s journey is to come close.”

And, in the meantime, for people like Chukurah Ali, the technology is already a welcome stand-in. She says she has recommended the Wysa app to many of her friends. She says she also finds herself passing along advice she’s picked up from the app, asking friends, “Oh, what you gonna do today to make you feel better? How about you try this today?”

It isn’t just the technology that is trying to act human, she says, and laughs. She’s now begun mimicking the technology.